APRI as a predictor of early viral response in chronic hepatitis C patients

Table 1 Patient’s baseline characteristics (n = 80)

Variable	mean ± SD	Range
Age (yr)	42.9 ± 12	19-74
Weight (kg)	70 ± 11.19	47-100
Hemoglobin (g/dL)	14.8 ± 1.92	8.1-19
Platelets (No/µL)	209 000 ± 84 429	57 300-444 000
Leucocytes (cells/µL)	5.8 ± 1.87	2.9-13.2
Glucose (mg/dL)	101 ± 18.94	73-172
Creatinine (mg/dL)	0.96 ± 0.26	0.6-1.2
Albumin (g/dL)	4.4 ± 0.51	2.9-5.5
AST (IU/dL)	64.6 ± 48.74	17-253
ALT (IU/dL)	76.3 ± 63.08	14-249
LDH (IU/dL)	272.6 ± 90.96	116-704
AP (IU/dL)	106.4 ± 40.37	51-240
Baseline viral load (IU/mL)	2 269 061 ± 7 220 266	1200-56 000 000
APRI	1.61 ± 1.90	0.17-9.0

AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; LDH: Lactate dehydrogenase; AP: Alkaline phosphatase; APRI: AST to platelet ratio index.

Table 2 Clinical characteristics in EVR and non-EVR patients (n = 80)

Variable	EVR patients (n = 54)	Non-EVR patients (n = 26)	P value
Age (yr)	43.61 ± 11.92	41.65 ± 12.90	0.505
Weight (kg)	71.09 ± 11.77	68.69 ± 9.88	0.372
WBC (cells/mm3)	5,824 ± 1.901	5.040 ± 1.850	0.820
Hemoglobin (g/dL)	14.86 ± 2.05	14.77 ± 1.74	0.855
Platelets (No/μL)	212,162 ± 79.956	207 815 ± 94 603	0.781
Glucose (mg/dL)	101.16 ± 18.94	99.96 ± 17.13	0.697
Creatinine (mg/dL)	0.97 ± 0.31	0.93 ± 0.11	0.552
AST (IU/mL)	62.07 ± 46.52	69.84 ± 53.64	0.508
ALT (IU/mL)	72.81 ± 62.15	83.61 ± 65.62	0.477
LDH (IU/mL)	276.96 ± 99.77	263.65 ± 70.12	0.543
HCV RNA viral load (copies/mL)	2 243 191 ± 7 664 170	2 322 791 ± 6 263 297	0.964
APRI	1.47 ± 1.63	1.90 ± 2.37	0.353

EVR: Early viral response; HCV: Hepatitis C virus.

Table 3 Factors associated with EVR (Univariate analysis)

Variable	OR	95% CI	P value
Sex	1.079	0.797-1.491	0.624
Age > 40 years old	1.570	0.609-4.090	0.346
Weight > 75 kg	1.299	0.491-3.437	0.598
Platelets < 150 000/μL	0.776	0.264-2.280	0.644
Albumin < 3.5g/dL	1.471	0.144-14.863	1.0
ALT > 28 IU/dL	1.320	0.421-4.135	0.633
Viral load > 600 000 IU/mL	0.944	0.352-2.533	0.910
Genotype 1 vs genotype other than 1	0.286	0.086-0.834	0.034a
APRI > 1.2	0.615	0.229-1.655	0.334

Chi square.

^aP < 0.05.

Table 4 Factors associated with EVR (multivariate analysis)

Variable	EVR	95% CI	P value
Age > 40 years old	1.420	0.489-4.166	0.515
Weight > 75 kg	1.214	0.435-3.384	0.711
ALT > 28 IU/dL	1.645	0.469-5.773	0.437
Viral load > 600 000 IU/mL	0.946	0.328-2.729	0.919
Genotype 1 vs genotype other than 1	0.304	0.087-0.946	0.041
APRI > 1.2	0.469	0.151-1.457	0.190

Logistic regression model.