Multifocal stenosing ulceration of the small intestine

Table 1 Other causes of multifocal small-bowel ulceration and stenosis

Ulcerative jejunoileitis with celiac disease or sprue-like intestinal disease

Lymphoma (especially mucosa only), including T-cell enteropathy and α-chain disease (Mediterranean type)

Crohn’s disease involving the small intestine

Infections (e.g. Campylobacter and Shigella)

Drug-induced type (especially with NSAIDs)

Zollinger–Ellison syndrome (gastrinoma) or other hypersecretory disorders

Traumatic injury (e.g. endoscopic or surgical treatment, seat-belt injury)

Ischemia related to vasculopathy (e.g. collagen vascular disease, coagulopathy, or inflammatory vasculitis)

NSAIDs: Nonsteroidal anti-inflammatory drugs.

Table 2 Differentiation of CMUSE from Crohn’s disease

Absence of clinical or laboratory features of an inflammatory syndrome

Absence of small-intestinal transmural inflammatory process or ulceration

Absence of small-intestinal giant-cell granulomatous inflammatory process

Absence of small-intestinal fistula formation despite recurrent chronic disease

Absence of disease in other parts of gastrointestinal tract (i.e. stomach or colon)

Absence of most extraintestinal features of Crohn’s disease (e.g. skin manifestations)

CMUSE: Cryptogenic multifocal ulcerous stenosing enteritis.