Effect of Lonicerae Flos extracts on reflux esophagitis with antioxidant activity

Table 1 Changes on the esophageal and gastric histomorphometry in RE rats

Group	Damage protecting percentages (%)	Inflammatory cells infiltration in esophagus (%)	Thickness of mucosa in esophagus (μm)	Hemorrhage depth in stomach (mm)
Controls
Sham	1.23 ± 0.13	0.86 ± 0.7	261.89 ± 23.67	0.003 ± 0.005
RE	12.72 ± 3.81b	94.80 ± 4.07b	20.81 ± 46.53b	0.963 ± 0.343
α-tocopherol	29.15 ± 10.23bc	72.53 ± 1.17bd	57.12 ± 43.83b	0.19 ± 0.11bd
LF extracts (mg/kg)
125	24.86 ± 4.8bd	78.92 ± 10.42bc	138.56 ± 48.8ad	0.13 ± 0.08bd
250	26.56 ± 8.8bc	68.31 ± 10.79bd	99.75 ± 85.6b	0.18 ± 0.08bd
500	46.41 ± 17.77bc	56.11 ± 4.05bd	118.64 ± 80.38ac	0.25 ± 0.18bd

Values are expressed mean ± SD of five rats;

^aP < 0.05 and

^bP < 0.01 compared to sham control;

^cP < 0.05 and

^dP < 0.01 compared to RE control; RE: Reflux esophagitis; LF: Lonicerae Flos.

Table 2 Changes on the stomach antioxidant systems in RE rats

Group	MDA (nmol/g tissue)	GSH (μmol/g tissue)	SOD (U/g protein)	CAT (U/g tissue)
Controls
Sham	10.11 ± 1.21	1.61 ± 0.29	64.83 ± 6.80	4.95 ± 0.69
RE	16.39 ± 0.75b	0.91 ± 0.22b	42.67 ± 6.70b	3.19 ± 0.56b
α-tocopherol	11.92 ± 0.94ac	1.18 ± 0.13bc	54.08 ± 6.79bd	4.08 ± 0.50ac
LF extracts (mg/kg)
125	15.05 ± 1.14b	1.03 ± 0.15b	49.04 ± 5.36b	3.78 ± 0.81b
250	12.11 ± 1.61bd	1.19 ± 0.17bc	53.58 ± 4.80bd	4.04 ± 0.28ac
500	10.54 ± 1.54d	1.31 ± 0.20ad	60.26 ± 5.22d	4.41 ± 0.46d

Values are expressed mean ± SD of five rats;

^aP < 0.05 and

^bP < 0.01 compared to sham control;

^cP < 0.05 and

^dP < 0.01 compared to RE control; MDA: Malondialdehyde; GSH: Glutathione; SOD: Superoxide dismutase; CAT: Catalase.