Effects of contrast media on the hepato-pancreato-biliary system

Table 1 Histopathological changes in the liver of rats, extrahepatic biliary ducts, and pancreas¹

Histopathologic changes	Group						P value
	1	1p	2	2p	3	3p
Liver of rats
Portal area inflammation	1	2	10a	10a	10a	10a	< 0.05
Bile duct inflammation	0	0	0	0	0	0	> 0.05
Periductal fibrosis	0	0	0	0	0	0	> 0.05
Bile duct proliferation	0	0	8a	10a	3	4	< 0.05
Hepatocyte necrosis	0	1	10a	10a	10a	10a	< 0.05
Parenchymal necrosis	0	0	0	0	0	0	> 0.05
Kupffer’s cell hyperplasia	1	2	10a	10a	10a	10a	< 0.05
Regeneration findings	1	2	10a	8a	2	1	< 0.05
Fibrosis	0	0	0	0	0	0	> 0.05
Extrahepatic biliary ducts
Inflammation	2	2	2	3	2	3	> 0.05
Fibroblastic proliferation	0	0	4a	5a	0	0	< 0.05
Necrosis	0	0	0	0	0	0	> 0.05
Pancreas
Hemorrhage	0	0	0	0	0	0	> 0.05
Necrosis	0	0	0	0	0	0	> 0.05
Inflammation	1	1	1	1	2	2	> 0.05

¹Numbers indicate the number of the animals in which histopathological changes have occurred;

^aIndicates the statistical significance.