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World J Gastroenterol. Sep 21, 2009; 15(35): 4372-4379
Published online Sep 21, 2009. doi: 10.3748/wjg.15.4372
Published online Sep 21, 2009. doi: 10.3748/wjg.15.4372
Dermatologic disorder | Cutaneous manifestations | Localization | Associated gastrointestinal malignancy |
Acanthosis nigricans | Pigmented papillomatous plaques | Axillar and inguinal folds, submammary and mammilla region, ano-genital regions | Gastric carcinoma; Colorectal carcinoma |
Palmo-plantar keratoderma | Diffuse epidermal thickening with rugose appearance | Palms, fingers and soles | Gastric carcinoma; Hepatic metastases |
Acrokeratosis paraneoplastica (Bazex syndrome) | Erythematous psoriasiform plaques | Hands, feet, ears, nose, elbows and knees | Squamous cell carcinoma of oropharynx/esophagus; Adenocarcinoma |
Leser-Trélat syndrome | Multiple seborrheic keratoses | Trunk and extremities | Gastric carcinoma; Colorectal carcinoma; Esophageal carcinoma; Pancreatic carcinoma |
Muir-Torre syndrome | Sebaceous adenomas; Sebaceous carcinomas; Keratoacanthomas | Head, trunk and extremities | Colorectal carcinoma; Colorectal adenomatous polyps |
Paraneoplastic dermatomyositis | Periorbital heliotrope erythema and edema; Gottron papules; Gottron sign | Eyelids, upper cheeks, forehead; Phalangeal joints; Elbows, knees | Colorectal carcinoma; Gastic carcinoma; Hepatocellular carcinoma |
Paraneoplastic pemphigus | Erosions; Vesicles and blisters, Erythematous to violaceous patches papules, plaques | Oral cavity; Head, trunk and extremities | Castleman’s disease; Sarcoma; Adenocarcinoma; Squamous cell carcinoma |
Peutz-Jeghers syndrome | Hyperpigmented macules | Buccal mucosa, gums; Tips of the fingers and toes | Multiple intestinal polyps; Colorectal carcinoma; Pancreatic carcinoma; Gastic carcinoma; Small bowel carcinoma |
Cronkhite-Canada syndrome | Hyperpigmented macules; Nail plate separation, discoloration and atrophy; Alopecia | Hands, palms, arms, neck and face; Fingernails and toenails; Scalp | Hamartomatous polyps; Colon carcinoma; Gastic carcinoma |
Paraneoplastic hypertrichosis lanuginosa acquisita | Lanugo hairs | Head, trunk and extremities | Colorectal carcinoma; Pancreatic carcinoma |
- Citation: Dourmishev LA, Draganov PV. Paraneoplastic dermatological manifestation of gastrointestinal malignancies. World J Gastroenterol 2009; 15(35): 4372-4379
- URL: https://www.wjgnet.com/1007-9327/full/v15/i35/4372.htm
- DOI: https://dx.doi.org/10.3748/wjg.15.4372