Saif MW. Secondary hepatic resection as a therapeutic goal in advanced colorectal cancer. World J Gastroenterol 2009; 15(31): 3855-3864 [PMID: 19701965 DOI: 10.3748/wjg.15.3855]
Corresponding Author of This Article
Muhammad Wasif Saif, MD, Associate Professor, Yale Medical Oncology, 800 Howard Avenue, Yale Physicians Building, 2nd Floor, New Haven, CT 06519, United States. wasif.saif@yale.edu
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Review
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Table 5 Secondary resection in patients with initially unresectable liver metastases
Improve patient selection through early and continued consultation in a multidisciplinary team approach, including close cooperation among a radiologist, medical oncologist, and surgeon with experience in liver resection
Conduct surgical evaluation at baseline and, if disease is initially unresectable, reevaluation at intervals during therapy to determine if conversion to resectability has been achieved
Set appropriate goals of therapy (best response, conversion to resectable disease, or palliation)
Determine length of therapy, with consideration for the risk of potential toxicities
Consider the safety profile of individual agents and the risks of overtreatment, including hepatotoxicity
If the treatment goal is conversion to resection, treat to resectability and not to best response
Citation: Saif MW. Secondary hepatic resection as a therapeutic goal in advanced colorectal cancer. World J Gastroenterol 2009; 15(31): 3855-3864