Bone mineral density and disorders of mineral metabolism in chronic liver disease

Table 1 Demographic data of patients with normal and low BMD

Parameter	Low BMD	Normal BMD	P value
Age (yr)	44.4 ± 6.1 (47)	42 ± 8.7 (45.5)	0.220
BMI (kg/m2)	21.14 ± 3.55 (20.3)	23.16 ± 5.46 (22.4)	0.275
Child score	7.4 ± 1.8 (7)	7.85 ± 1.9 (8)	0.350
Lean body mass (kg)	43.3 ± 7.3 (43)	46.7 ± 8.75 (44.7)	0.290
Fat mass (kg)	11.6 ± 6.5 (11.2)	14.4 ± 7.1 (12.43)	0.150

BMD: Bone mineral density. Parameters are expressed as mean ± SD. Median value is given in parentheses.

Table 2 Sunlight exposure, physical activity and dietary parameters in men with normal and low BMD

Parameter		Low BMD	Normal BMD	P value
Sun index	Past	2.49 ± 3.3 (1.3)	3.54 ± 5.3(2.5)	0.13
	Present	0.21 ± 0.41 (0)	0.83 ± 1.4 (0.15)	0.035a
Physical activity (MET.min/wk)	Past	2188 ± 2340 (1920)	2378 ± 1855(2450)	0.7
	Present	468 ± 1260 (0)	351 ± 659.7 (120)	0.47
Total Calorie (kcal/d)	Past	2111 ± 768 (2078)	1867 ± 524 (1878.0)	0.18
	Present	2020 ± 662 (2071)	1997 ± 422 (2078)	0.65
Total Proteins (g/d)	Past	59.9 ± 22.6 (59.7)	54.9 ± 20 (56)	0.3
	Present	59.3 ± 20.7 (50.6)	60.2 ± 18.6 (61.2)	0.56
Calcium (mg/d)	Past	550 ± 160 (426.5)	582.6 ± 197 (557.8)	0.45
	Present	528 ± 180.7 (391.3)	620.3 ± 259.7(639.8)	0.3
Phosphorus (mg/d)		1436 ± 652 (1478)	1214.8 ± 535.7(1202)	0.1
Salt intake (g/d)		6.9 ± 2.9 (7)	7.2 ± 2.8(7.4)	0.53

^aStatistically significant, P < 0.05.

Table 3 Biochemical parameters and markers of bone turnover in men with normal and low BMD

Parameter	Low BMD	Normal BMD	P value
Serum calcium (mg/dL1)	9.17 ± 0.52 (9.22)	9.29 ± 0.47 (9.33)	0.29
Serum phosphorus ( mg/dL)	3.63 ± .9 (3.59)	3.74 ± 1 (3.8)	0.69
Serum alkaline phosphatase (IU/L)	138 ± 61 (132.7)	140.2 ± 65.6(128.5)	0.96
Serum magnesium ( mg/dL)	2.0 ± 1.9 (1.58)	1.42 ± 0.3 (1.48)	0.08
Urine calcium/creatinine ratio	0.06 ± 0.1 (.03)	0.053 ± 0.053 (0.035)	0.72
25 (OH) vit D (ng/mL)	11.2 ± 7.6 (9.4)	10.5 ± 5.7 (8)	0.90
1,25 (OH)2 vitD (pg/mL)	46.54 ± 26.4 (41)	36.6 ± 21.6 (30)	0.19
Serum PTH (pg/mL)	45.5 ± 28.1 (43.9)	42.2 ± 18.9 (42.1)	0.95
Serum osteocalcin (ng/mL)	2.99 ± 2.5 (1.8)	2.14 ± 1.8 (1.14)	0.37
UDPD/creatinine ratio2	11.5 ± 4.5 (12.1)	12.5 ± 6.2 (11.6)	0.84

¹Corrected calcium is used;

²Unit - nM DPD/mmol/L creatinine.

Table 4 Hormone parameters in men with normal and low BMD

Parameter	Low BMD	Normal BMD	P value
FSH (IU/L)	8.2 ± 9.4 (4.62)	19.8 ± 40.2 (7.53)	0.34
LH (IU/L)	6.8 ± 6.2 (4.78)	11.1 ± 13.9 (6.47)	0.31
Estradiol (pg/mL)	76.1 ± 61.5 (63.8)	100.6 ± 61.8 (79.2)	0.021
SHBG (nmol/L)	76.7 ± 31.1 (75.4)	72.3 ± 25.4 (72.6)	0.60
Free testosterone2 (ng/dL)	7.6 ± 4.7 (7.27)	7.2 ± 4.0 (7.06)	0.85
IGF-1 (pmol/L)	44.8 ± 24.7 (35.2)	73.7 ± 58.54 (38.4)	0.0491
IGFBP3 (&mgr;g/mL)	1.21 ± 0.6 (1.03)	1.8 ± 1.2 (1.51)	0.071

¹Statistically significant, P < 0.05;

²Calculated from total testosterone.