Human papilloma virus and esophageal carcinoma in a Latin-American region

Table 1 HPV detection frequency according to subjects’ demographic factors and lifestyles, and the clinicopathological features of esophageal carcinoma

	Total (%)	HPV- (%)	HPV+ (%)	P value
Total	60 (100)	45 (75)	15 (25)
Gender				0.485
Female	13 (100)	11 (85)	2 (15)
Male	47 (100)	34 (72)	13 (28)
Alcohol consumption				0.377 (0.420)
No	10 (100)	9 (90)	1 (10)
Yes	36 (100)	27 (75)	9 (25)
Unknown	14 (100)	9 (64)	5 (36)
Smoking				0.274 (0.450)
No	16 (100)	14 (88)	2 (12)
Yes	28 (100)	21 (75)	7 (25)
Unknown	16 (100)	10 (63)	6 (37)
Esophageal location				0.330
Upper third	14 (100)	9 (64)	5 (36)
Upper/middle third	4 (100)	2 (50)	2 (50)
Middle third	28 (100)	23 (82)	5 (28)
Middle/lower third	10 (100)	7 (70)	3 (30)
Lower third	4 (100)	4 (100)	0 (0)
Histologic grade				0.222
Basaloid/poorly differentiated	1 (100)	1 (100)	0 (0)
Poorly differentiated	20 (100)	17 (85)	3 (15)
Moderately-differentiated	38 (100)	27 (71)	11 (29)
Well-differentiated	1 (100)	0 (0)	1 (100)

P values in parentheses are those without “unknown” category.

Table 2 HPV genotypes detected in ESCCs

HPV genotype	n (%)
HPV-16	6 (40)
HPV-18	5 (33)
HPV-59	1 (7)
Unknown	3 (20)
Total	15 (100)

ESCCs: Esophageal squamous cell carcinomas.