Enteropathic spondyloarthropathy: A common genetic background with inflammatory bowel disease?

Table 1 HLA associations in IBD and IBD-associated arthropathy[11]

	HLA antigens investigated	Percentage in IBD + arthropathy affected patients	Percentage in IBD patients without arthropathy
AS	HLA-B*27	60	7
TypeIarthritis	HLA-B*27	26	7
	HLA-B*35	33	15
	HLA-DRB1*0103	35	3
Type II arthritis	HLA-B*44	62	31

Table 2 Candidates genes and loci in CD and UC

	Genes and loci	Associated with CD	Associated with UC
1p31	IL23R	Yes	Yes
1q21	ECM1	-	Yes
2q37	ATG16L1	Yes	No
3p21	Several included MST1-BSN	Yes	Yes
5p13	Intergenic, PTGR4	Yes	No
5q31	Several included SLC22A5	Yes	Yes
5q33	IRGM	Yes	No
5q33	IL12B	Yes	Yes
6q21	HLA-DQ/DR	Yes	Yes
10q21	ZNF365	Yes	Yes
10q24	NKX2-3	Yes	Yes
16q12	NOD2	Yes	No
17q21	Several included STAT3	Yes	Yes
18p11	PTPN2	Yes	Yes

CD: Crohn’s disease; UC: Ulcerative colitis.