Copyright
©2009 The WJG Press and Baishideng.
World J Gastroenterol. May 14, 2009; 15(18): 2184-2189
Published online May 14, 2009. doi: 10.3748/wjg.15.2184
Published online May 14, 2009. doi: 10.3748/wjg.15.2184
STAT protein | Activating factor | Activation effect |
STAT 1 | IFN-α/β (type I INF) IFN-γ (type II INF) | Antiviral response, inflammation and hepatocyte damage development, apoptosis stimulation |
STAT 2 | INF-α/β i INF-λ | Antiviral response |
STAT 3 | IL-6 and its family, IL-10, IL-22, EGF, HCV proteins | Participates in antiviral IFN-α effect, direct cytoprotective and anti-inflammatory influence on hepatocytes |
STAT 4 | IL-12 | Probably plays a critical role in hepatocytes damage during hepatic ischemia/reperfusion injury and in Th1 differentiation |
STAT 5 | Growth factors | Regulates the genes expression essential for hepatocytes metabolism, growth and differentiation |
STAT 6 | IL-4, IL-12 and IL-13 | Participates in Th2 lymphocytes response during viral hepatitis and decreases hepatocytes damage during hepatic ischemia/reperfusion injury |
- Citation: Dabrowska MM, Panasiuk A, Flisiak R. Signal transduction pathways in liver and the influence of hepatitis C virus infection on their activities. World J Gastroenterol 2009; 15(18): 2184-2189
- URL: https://www.wjgnet.com/1007-9327/full/v15/i18/2184.htm
- DOI: https://dx.doi.org/10.3748/wjg.15.2184