Altered spontaneous contractions of the ileum by anesthetic agents in rats exposed to peritonitis

Table 1 Effects of Propofol, midazolam and dexmedetomidine on spontaneous contractions in experiment groups

	Control	Peritonitis
Amplitude (%)1	85.2 ± 6.6 (100)	47.4 ± 7.1a (100)
Propofol	49.6 ± 4.8b	59.4 ± 5.2b
Midazolam	39.2 ± 4.5b	51.8 ± 5.0b
Dexmedetomidine	136.6 ± 5.8bc	152.0 ± 5.4bc
Frequency (#/10 min)	32.8 ± 4.6	20.2 ± 3.9a
Propofol	18.2 ± 3.4b	11.6 ± 3.2b
Midazolam	28.2 ± 3.8	17.4 ± 3.0
Dexmedetomidine	36.2 ± 4.0	22.2 ± 3.1

¹Amplitudes of the contractions induced by anesthetic agents from both control and peritonitis groups were calculated as the percentage of the initial spontaneous contractions;

^aP < 0.05 vs control;

^bP < 0.05 vs initial spontaneous contractions;

^cP < 0.05 vs propofol and midazolam.

Table 2 Effects of Propofol, midazolam and dexmedetomidine on amplitude and frequency of the spontaneous contractions

	Amplitude	Frequency
Propofol	Decreased	Decreased
Midazolam	Decreased	No significant change
Dexmedetomidine	Increased	No significant change