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©2008 The WJG Press and Baishideng.
World J Gastroenterol. Mar 7, 2008; 14(9): 1425-1429
Published online Mar 7, 2008. doi: 10.3748/wjg.14.1425
Published online Mar 7, 2008. doi: 10.3748/wjg.14.1425
Table 1A Volumes of RBCs transfused intraoperatively in the 4 studies
Study | Aprotinin group | Control group | yi (95% CI) | ||||
Mean | SD | n | Mean | SD | n | ||
(units) | (units) | (units) | (units) | ||||
1 Garcia HL | 13.0 | 8.0 | 39 | 14.4 | 9.7 | 41 | -1.4 (-5.29, 2.49) |
2 Marcel RJ | 2.1 | 2.0 | 21 | 3.0 | 4.4 | 23 | -0.9 (-2.89, 1.09) |
3 Dalmau A1 | 2.44 | 3.03 | 63 | 2.14 | 2.32 | 64 | 0.3 (-0.64, 1.24) |
4 Llamas P | 8.1 | 5.2 | 20 | 13 | 7.4 | 30 | -4.9 (-8.39, -1.41) |
Table 1B Weighted mean differences (WMDs) in the volumes of RBCs transfused intraoperatively
Heterogeneity | WMD | Z test | 95% CI | |||
Q | P | (units) | Z | P | ||
A | 8.87 | 0.03 | -1.23 | 1.24 | 0.21 | -3.17 to 0.71 |
B | 3.85 | 0.15 | -1.80 | 2.23 | 0.03 | -3.38 to -0.22 |
Table 2A Volumes of FFP transfused intraoperatively in the 4 studies
Study | Aprotinin group | Control group | yi (95% CI) | ||||
Mean | SD | n | Mean | SD | n | ||
(units) | (units) | (units) | (units) | ||||
1 Garcia HL | 26.0 | 16.0 | 39 | 28.0 | 15.0 | 41 | -2.00 (-8.80, 4.80) |
2 Marcel RJ | 3.6 | 3.5 | 21 | 6.6 | 6.1 | 23 | -3.00 (-5.91, -0.09) |
3 Dalmau A1 | 1.09 | 2.20 | 63 | 1.20 | 2.21 | 64 | -0.11 (-0.88, 0.66) |
4 Llamas P | 16.7 | 10.4 | 20 | 28 | 14 | 30 | -11.3 (-18.07, -4.53) |
Table 2B Weighted mean differences (WMDs) in the volumes of FFP transfused intraoperatively
Heterogeneity | WMD | Z test | 95% CI | |||
Q | P | (units) | Z | P | ||
A | 13.77 | 0.003 | -3.13 | 1.68 | 0.09 | -6.79 to 0.53 |
B | 5.25 | 0.07 | -3.99 | 3.14 | 0.002 | -6.47 to -1.50 |
Table 3A Postoperative outcomes of the 5 studies
Study | Aprotinin group | Control group | ORi1, 95% CI | ORi2, 95% CI | ORi3, 95% CI | ||||||
n | n1 | n2 | n3 | n | n1 | n2 | n3 | ||||
1 James Y | 33 | 0 | 1 | 1 | 30 | 1 | 4 | 2 | 0.29 (0.01, 7.48) | 0.20 (0.02, 1.93) | 0.44 (0.04, 5.09) |
2 Garcia HL | 39 | 1 | 2 | 41 | 1 | 3 | 1.05 (0.06, 17.43) | 0.68 (0.11, 4.34) | |||
3 Porte RJ | 89 | 5 | 7 | 2 | 48 | 5 | 2 | 3 | 0.51 (0.14, 1.87) | 1.96 (0.39, 9.85) | 0.34 (0.06, 2.14) |
4 Dalmau A1 | 63 | 1 | 2 | 2 | 64 | 4 | 2 | 4 | 0.24 (0.03, 2.23) | 1.02 (0.14, 7.45) | 0.49 (0.09, 2.79) |
5 Llamas P | 20 | 4 | 0 | 50 | 6 | 7 | 1.83 (0.46, 7.35) | 0.14 (0.01, 2.60) |
Table 3B Odds ratios of the postoperative outcomes
Heterogeneity of ORi | OR | χ2 test | 95% CI | ||||
Q | P | χ2 | P | ||||
Death | A | 3.32 | 0.51 | 0.69 | 0.48 | > 0.05 | 0.32-1.52 |
B | 2.21 | 0.53 | 0.85 | 0.06 | > 0.05 | 0.36-2.00 | |
Laparotomy for bleeding | A | 4.09 | 0.39 | 0.65 | 0.44 | > 0.05 | 0.29-1.43 |
B | 3.94 | 0.27 | 0.59 | 0.57 | > 0.05 | 0.25-1.41 | |
Thrombotic events | A | 0.08 | 0.96 | 0.42 | 2.33 | > 0.05 | 0.14-1.30 |
B | 0.02 | 0.88 | 0.38 | 1.75 | > 0.05 | 0.09-1.64 |
- Citation: Liu CM, Chen J, Wang XH. Requirements for transfusion and postoperative outcomes in orthotopic liver transplantation: A meta-analysis on aprotinin. World J Gastroenterol 2008; 14(9): 1425-1429
- URL: https://www.wjgnet.com/1007-9327/full/v14/i9/1425.htm
- DOI: https://dx.doi.org/10.3748/wjg.14.1425