Role of genetic disorders in acute recurrent pancreatitis

Table 1 Mutations in different groups of patients suffering from pancreatitis

Clinical characteristic of chronic pancreatitis	% of all patients	With mutation		Without mutation
		Type of mutation	%	%
Autosomal-dominant	1	PRSS1:R122H, N29I	70-80	10-20
		PRSS1:triplication	10-20
Familial	3	PRSS1:R122H, N29I	15	50
		PRSS1:A16V	< 5
		SPINK1:N34S	30
		Other SPINK1 mutations	5
Sporadic	20	PRSS1:R122H, N29I	<< 1	15-50
		PRSS1:A16V	< 5
		SPINK1:N34S	20-40
		CFTR:various	20-40
Alcoholic	75-80	SPINK1:N34S	5	85
		CFTR:various	10
Pancreas divisum	3	CFTR:various	20	80
Tropical pancreatitis	?	SPINK1:N34S	50	50
All groups: protective mutation	1	PRSS1:G191R	In controls: 3