Chemokine system polymorphisms, survival and hepatocellular carcinoma occurrence in patients with hepatitis C virus-related cirrhosis

Table 1 Characteristics and outcome of patients with HCV-related cirrhosis classified according to MCP1, CCR5 and SDF-1 genotypes

	MCP1 genotype (n = 98)			CCR5 genotype (n = 120)			SDF-1 genotype (n = 120)
	MCP-1/MCP-1 homozygotes	Heterozygotes or homozygotes for MCP-1 (-2518) allele		CCR5/CCR5 homozygotes	Heterozygotes or homozygotes for CCR5Δ32 allele		SDF-1/SDF-1 homozygotes	Heterozygotes or homozygotes for SDF-1 3’A allele
	(n = 56)	(n = 42)	P	(n = 106)	(n = 14)	P	(n = 65)	(n = 55)	P
	57.2%	42.8%		88.4%	11.6%		54.1%	45.9%
Age (yr)12	58.7 ± 12.3	58.5 ± 11.8	0.9	58.7 ± 12.1	56.6 ± 13.1	0.7	57.3 ± 11.5	59.8 ± 13.0	0.1
Male gender13	31 (55.3)	17 (40.4)	0.1	53 (50.0)	8 (57.1)	0.7	35 (53.8)	25 (45.4)	0.4
ALT (× ULN)12	2.6 ± 1.0	2.9 ± 1.2	0.5	2.8 ± 1.2	2.2 ± 0.6	0.03	2.7 ± 1.8	2.8 ± 1.1	0.7
AST (× ULN)12	2.1 ± 0.8	2.1 ± 0.7	0.9	2.2 ± 0.8	1.6 ± 0.6	0.008	2.1 ± 0.8	2.2 ± 0.9	0.6
Platelet count (103/mm3)12	138.3 ± 64.7	142.8 ± 65.0	0.5	138.3 ± 64.7	142.8 ± 65.0	0.5	128.6 ± 60.1	152.9 ± 71.3	0.07
Child Pugh score12	5.1 ± 0.6	5.1 ± 0.7	0.4	5.2 ± 0.7	5.0 ± 0.2	0.6	5.2 ± 0.8	5.1 ± 0.5	0.2
MCP1 serum levels (pg/mL)12	448 ± 150	564 ± 168	0.9	-	-	-	-	-	-
RANTES serum levels (pg/mL)12	-	-	-	28847 ± 18878	29576 ± 15905	0.6	-	-	-
SDF-1 serum levels (pg/mL)12	-	-	-	-	-	-	2347 ± 690	2201 ± 333	0.7
HCV genotype 13	40 (71.4)	35 (83.3)	0.2	82 (77.3)	13 (92.8)	0.2	49 (75.3)	46 (83.6)	0.3
Anti-viral treatment3	32 (57.1)	26 (61.9)	0.6	62 (58.4)	10 (71.4)	0.4	44 67.9)	28 (52.7)	0.1
Sustained virological3 Response	14 (25.0)	11 (26.1)	0.9	25 (23.5)	3 (21.4)	0.9	16 (24.6)	12 (21.8)	0.8
HCC development3	17 (30.3)	19 (45.2)	0.1	43 (40.5)	4 (28.5)	0.5	26 (40.0)	21 (38.1)	0.7
Death3	10 (17.8)	6 (14.2)	0.7	20 (18.8)	3 (21.4)	0.7	11 (16.9)	12 (21.8)	0.4

¹Parameters recorded at inclusion.

²mean ± SD.

³Number (percentage) of patients. ALT: Alanine aminotransferase; AST: Aspartate transaminase; HCV: Hepatitis C virus; HCC: Hepatocellular carcinoma occurrence.