Increased prevalence of symptoms of gastroesophageal reflux diseases in type 2 diabetics with neuropathy

Table 1 Prevalence of GERD symptoms in DM patients with and without neuropathy

	DM	DM w Neuro	DM w/o Neuro	P value
	150	46	104
Age (yr)	54 ± 15	56 ± 13	53 ± 16	> 0.10
DM Duration (yr)	12 ± 9.2	14.8 ± 9.1	10.7 ± 9.0	> 0.10
Weight (lbs)	198 ± 54	207 ± 42	194 ± 58	> 0.10
BMI	32 ± 7.2	33.9 ± 6.9	31.2 ± 7.2	> 0.10
HbA1c (%)	7.7 ± 2.0	7.9 ± 1.8	7.7 ± 1.2	> 0.10
Metformin	87/150 (58%)	26/46 (56.5%)	61/104 (58.6%)	> 0.10
GERD	61/150 (40.7%)	27/46 (58.7%)	34/104 (32.7%)	< 0.01
Heartburn	45/150 (30%)	20/46 (43.5%)	25/104 (24%)	< 0.05
Chest pain	10/150 (6.6%)	5/46 10.9%)	5/104 (4.8%)	< 0.05
Chronic cough	14/150 (9.4%)	8/46 (17.8%)	7/104 (6.7%)	< 0.05
Regurgitation	19/150 (12.8%)	7/46 (15.6%)	12/104 (11.5%)	> 0.10
Hoarseness	5/150 (3.3%)	2/46 (4.4%)	3/104 (2.9%)	> 0.10

GERD: Presence of one or more of the five symptoms. Prevalence of heartburn in US adults is 14% weekly[11].