Metrically measuring liver biopsy: A chronic hepatitis B and C computer-aided morphologic description

Table 1 Quantitative parameters automatically obtained with the Metriser

Parameter	min	max
Residual hepatocellular set
Residual hepatocellular set (%)	67.97	99.59
Inflammation
Inflammatory cell cluster space (%)	0	8.71
Pure inflammatory cell cluster space (%)	0	3.67
Extra-basin inflammatory space (%)	0	1.14
Fibrosis
Area of Sample covered by fibrosis (%)	0	32
Islets magnitude
10-103 (%)	8.9	100
103-104 (%)	0	58.15
> 104 (%)	0	87.4
Wrinkledness	0	1666
Tectonic Index
Liver tissue	0	0.78
Low or no disorder	0	0.4
Middle disorder	0.4	0.6
High disorder	0.6	1

Data are expressed as percentage of true liver surface. The value 0 is obtained when no cell clusters were recognized. Quantitative evaluation of steatosis. At this phase of the research this quantitative parameter is still obtained with an ad hoc software.

Table 2 Differences between the uncorrected and fractal-corrected IS measurements of fibrosis surface extension

n	Uncorrected fibrosis extension range (%)	Mean increase of fibrosis extension after IS meter correction (%)	min (%)	max (%)
193	0-3	25	0	65
156	3-10	10	5	18
49	10-40	4	2	6

n: Number of liver biopsy.

Table 3 Residual parenchyma metrical and semi-quantitative case numbers

Δmetrical measure		Semi-quantitative evaluations
		HAI	Scheuer	Ishak	METAVIR	Average
Increase	24	19	26	26	23	23.5
Stationarity	0	30	23	18	25	24.0
Decrease	37	12	12	17	13	13.5

Mean value of the four semi-quantitative scoring systems; Data refer to the difference between two biopsies taken at different times.

Table 4 Inflammatory basin metrical and semi-quantitative case numbers

Δmetrical measure		Semi-quantitative evaluations
		HAI	Scheuer	Ishak	METAVIR	Average
Increase	35	16	16	23	7	15.5
Stationarity	1	25	22	19	36	25.5
Decrease	25	20	23	19	18	20.0

Mean value of the four semi-quantitative scoring systems; Data refer to the difference between two biopsies taken at different times.

Table 5 Fibrosis metrical and semi-quantitative case numbers

Δmetrical measure		Semi-quantitative evaluations
		HAI	Scheuer	Ishak	METAVIR	Average
Increase	42	19	26	26	23	23.5
Stationarity	0	30	23	18	25	24.0
Decrease	19	12	12	17	13	13.5

Mean value of the four semi-quantitative scoring systems; Data refer to the difference between two biopsies taken at different times.

Table 6 Tectonic Index metrical and semi-quantitative case numbers

Δof loss of the natural liver tissue order		Semi-quantitative evaluations
		HAI	Scheuer	Ishak	METAVIR	Average
Increase	46	19	26	26	23	23.5
Stationarity	3	30	23	18	25	24.0
Decrease	12	12	12	17	13	13.5

Mean value of the four semi-quantitative scoring systems; Data refer to the difference between two biopsies taken at different times.

Table 7 Side effects of liver biopsy sampling and other invasive techniques

Examination	Side effects		Ref.
	Serious complications (%)	Mortality (%)
Liver biopsy	0.5	> 0.02	31
Oesophagogastroduodenoscopy		0.01	31
Colonoscopy	0.3	0.02	31-33
Flexible sigmoidoscopy	0.0001		32, 34
Endoscopic retrograde cholangiopancreatography	5-10	0.1-1	32, 35, 36
Percutaneous transhepatic cholangiography	3		32
Contrast agents	2-10		37-39