Hepatitis B virus genotypes and lamivudine resistance mutations in Jordan

Table 1 Clinical and serological patterns of all 107 HBsAg positive patients n (%)

Criteria	HBeAg positive	HBeAg negative	P
Number of cases	18 (17)	89 (83)	< 0.0001
Hepatitis-related symptoms	6 (330)	0 (0)	< 0.0001
Positive HBeAb	0 (0)	89 (100)	< 0.0001
Abnormal ALT	18 (100)	35 (39)	< 0.0001
Abnormal AST	16 (89)	12 (13)	< 0.0001
Abnormal ALP	4 (22)	18 (20)	0.85

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase.

Table 2 Profile of detected YMDD mutations among tested cases

Mutation	Patients with history of lamivudine treatment	lamivudine naive patients
Patients tested	16	4
HBeAg Positive	3	1
M204Ile	4	0
M204V	1	1
L180M	1	0
Total	6	1