Effect of propranolol on the splanchnic and peripheral renin angiotensin system in cirrhotic patients

Table 1 Clinical characteristics and casual measurements of advanced liver disease outpatients (LD) treated with propranolol or not

Characteristics and measurements	LD with propranolol (n = 9)	LD without propranolol (n = 7)
Age (yrs)	45 ± 2	54 ± 5
Sex male/female	5 (55.6%)/4 (44.4%)	4 (57%)/3 (43%)
Child Pugh Score	9.8 ± 0.5	11.0 ± 0.8
MELD Score	27.1 ± 1.3	29.3 ± 2.1
Albumin (g/dL)	2.7 ± 0.2	2.4 ± 0.3
Bilirubin (mg/dL)	2.5 (1.3-5.1)	2.5 (1.2-7.1)
Creatinine (mg/dL)	1.2 (0.8-2.3)	1.0 (1.0-1.45)
INR (International Normalized Ratio)	1.62 (1.01-6.15)	1.55 (1.20-2.20)
Serum Na+ (mEq/L)	133.0 ± 1.6	126.0 ± 2.7a

Data are expressed as mean ± SE or median (25 and 75 percentile), except for sex where number of patients and percentages are shown.

^aP < 0.05 for the comparison of LD with propranolol and LD without propranolol (unpaired t test for mean comparisons and Mann-Whitney test for median comparisons).

Table 2 Clinical characteristics and casual measurements of patients undergoing liver transplantation (LT) pre-treated with propranolol or not

Characteristics and measurements	LT with propranolol (n = 10)	LT without propranolol (n = 11)
Age (yr)	50.6 ± 3.4	50.0 ± 2.6
Sex male/female	3 (30%)/7 (70%)	7 (63.6%)/4 (36.4%)
Child Pugh Score	10.5 ± 0.4	11.2 ± 0.6
MELD Score	28.0 ± 1.1	29.8 ± 1.6
Albumin (g/dL)	2.81 ± 0.09	2.61 ± 0.15
Bilirubin (mg/dL)	3.38 ± 1.20	3.70 ± 0.87
Creatinine (mg/dL)	1.0 (1.0-1.45)	1.05 (0.75-1.50)
INR (International Normalized Ratio)	1.36 (1.32-1.95)	1.69 (1.24-2.11)
Serum Na+ (mEq/L)	135.2 ± 1.0	130.1 ± 1.8a

Data are expressed as mean ± SE or median (25 and 75 percentile), except for sex where number of patients and percentages are shown.

^aP < 0.05 for the comparison of LT with propranolol and LT without propranolol (unpaired t test for mean comparisons and Mann-Whitney test for median comparisons).

Table 3 Ratios between angiotensins in peripheral circulation of advanced liver disease outpatients (LD) treated with propranolol or not

Angiotensin ratios	LD with propranolol (n = 9)	LD without propranolol (n = 7)
Ang II/Ang I	1.24 ± 0.30	0.21 ± 0.05a
Ang-(1-7)/Ang I	0.74 ± 0.19	0.09 ± 0.03a
Ang-(1-7)/Ang II	0.62 ± 0.06	0.42 ± 0.09

Data are expressed as mean ± SE.

^aP < 0.05 for the comparison of NLD with propranolol and NLD without propranolol (unpaired t test).

Table 4 Ratios between angiotensins in splanchnic circulation of patients undergoing liver transplantation (LT) pre-treated with propranolol or not

Angiotensin ratios	LT with propranolol (n = 10)	LT without propranolol (n = 11)
Ang II/Ang I	0.46 (0.26-2.64)	0.19 (0.13-0.24)a
Ang-(1-7)/Ang I	0.27 (0.06-0.91)	0.05 (0.04-0.11)
Ang-(1-7)/Ang II	0.43 ± 0.08	0.52 ± 0.12

Data are expressed as mean ± SE or median (25 and 75 percentile).

^aP < 0.05 for the comparison of LT with propranolol and LT without propranolol (unpaired t test for mean comparisons and Mann-Whitney test for median comparisons).