Helicobacter pylori infection and expression of DNA mismatch repair proteins

Table 1 Demographic and pathological findings of H pylori-positive and -negative patients n (%)

	Positive group	Negative group	P value
Age (mean ± SD, yr)	41.78 ± 15.21	46.58 ± 13.41	0.1
Male:female	28:22	23:27	0.32
Gastritis severity			0.45
1	8 (16)	13 (26)
2	34 (68)	29 (58)
3	8 (16)	8 (16)
Gastritis activity			0.23
0	8 (16)	15 (30)
1	6 (12)	9 (18)
2	28 (56)	20 (40)
3	8 (16)	6 (12)
Intestinal metaplasia			0.45
Positive	8 (16)	11(22)
Negative	42 (84)	39(78)
Atrophy			0.54
Positive	7 (14)	5 (10)
Negative	43 (86)	45 (90)
Dysplasia			0.31
Positive	3 (6)	1 (2)
Negative	47 (94)	49 (98)

Table 2 Immunohistochemical staining of gastric biopsy specimens from H pylori-positive and -negative patients

	Positive group	Negative group	P value
hMLH1
Body
Area	73.80 ± 11.77	85.28 ± 7.71	0.000
Intensity	2.02 ± 0.65	2.08 ± 0.63	0.64
Antrum
Area	72.44 ± 11.35	82.36 ± 9.63	0.000
Intensity	1.88 ± 0.59	1.92 ± 0.63	0.75
Overall
Area	73.34 ± 10.10	84.14 ± 7.32	0.000
Intensity	1.95 ± 0.47	1.99 ± 0.41	0.64
hMSH2
Body
Area	77.24 ± 11.36	81.28 ± 10.58	0.07
Intensity	1.96 ± 0.57	1.96 ± 0.64	1.00
Antrum
Area	78.76 ± 11.24	80.62 ± 10.89	0.40
Intensity	2.04 ± 0.53	1.90 ± 0.65	0.24
Overall
Area	78.24 ± 8.71	81.16 ± 8.32	0.09
Intensity	1.99 ± 0.42	1.93 ± 0.46	0.50