Evolution of systemic therapy of advanced hepatocellular carcinoma

Table 1 Pivotal chemotherapy trials in advanced HCC

Chemotherapy	Study	No. of patients	Response rate
Doxorubicin
Pegylated liposomal doxorubicin	Halm	16	0
Doxorubicin	Johnson	32	44
Doxorubicin, 5-FU, mitomycin C	Al-Idrissi	40	13
Doxorubicin, bleomycin	Ravry	60	16
Doxorubicin, cisplatin	Lee	37	18.9
Doxorubicin, 5-FU, cisplatin, interferon (PIAF)	Yeo	91	20.9
Cisplatin
Cisplatin	Falkson	35	17
Cisplatin, interferon	Ji	30	13.3
Cisplatin, 5-FU, mitoxantrone	Ikeda	51	27
Gemcitabine
Gemcitabine	Fuchs	30	0
Gemcitabine	Yang	28	18
Gemcitabine, oxaliplatin	Taieb	21	19
Epirubicin, etoposide
Epirubicin	Hochster	18	17
Etoposide	Melia	24	13
Epirubicin, etoposide	Bobbio- Pallavicini	36	39
Others
Mitoxantrone	Lai	20	0
Paclitaxel	Chao	20	0
Irofulven	Falcon- Lizaraso	29	7
Irinotecan	O'Reilly	14	7
Nolatrexed	Stuart	26	8
T138067	Leung	21	10
Capecitabine	Patt	37	11
5-FU, interferon	Patt	28	14