Anticancer activity of genistein on implanted tumor of human SG7901 cells in nude mice

Table 1 Inhibition effect of genistein on implanted tumors in nude mice (mean ± SD)

Groups dosage	Number of animals		Volume of tumors (mm3)		Inhibition rate (%)
	Beginning	Ending	Beginning	Endin
Control group
0.2 mL saline	5	5	20.6 ± 1.1	499.8 ± 11.8
DMSO
1.5 mg/kg	5	5	20.6 ± 1.3	509.4 ± 8.6
Genistein
1.5 mg/kg	5	5	20.3 ± 1.6	458.2 ± 6.7	10.8a
1.0 mg/kg	5	5	21.6 ± 1.6	359.7 ± 6.4	29.9a
1.5 mg/kg	5	5	21.5 ± 1.6	319.5 ± 10.6	39.6a

^aP < 0.05 vs the control group.

Table 2 Apoptotic index (AI) of implanted tumors in nude mice (%)

	AI
Control group
0.2 mL saline	12.6 ± 0.6
DMSO
1.5 mg/kg	13.4 ± 0.7
Genistein
0.5 mg/kg	28.9 ± 1.2
1.0 mg/kg	33.8 ± 1.6
1.5 mg/kg	37.7 ± 1.2

Table 3 Positive rate of bcl-2 proteins and positive rate of bax proteins of implanted tumors in nude mice (%)

	Positive rate of bcl-2 proteins	Positive rate of bax proteins
Control group
0.2 mL saline	18.4 ± 1.6	11.2 ± 0.8
DMSO
1.5 mg/kg	17.9 ± 0.7	11.9 ± 0.5
Genistein
0.5 mg/kg	11.9 ± 0.9	20.9 ± 1.7
1.0 mg/kg	5.9 ± 0.7	24.9 ± 0.8
1.5 mg/kg	4.2 ± 0.6	29.6 ± 1.7