Virologic characteristics of hepatitis B virus in patients infected via maternal-fetal transmission

Table 1 MHC-I binding predictions of 144-183 residue of HbcAg, processed by the SMM method

Allele	Position (aa)	Pep length	Sequence	IC50 (nm)1
HLA A*3101	148-157	10	VVRRRGRSPR	30.9
HLA A*3101	150-159	10	RRRGRSPRRR	13.7
HLA A*3101	157-166	10	RRRTPSPRRR	19.2
HLA A*3101	159-167	9	RTPSPRRRR	38.4
HLA A*3101	165-174	10	RRRSQSPRRR	19.2
HLA A*3101	166-175	10	RRSQSPRRRR	35.4
HLA A*3101	167-175	9	RSQSPRRRR	13.7
HLA A*3201	159-167	9	RTPSPRRRR	48.6
HLA A*6801	145-154	9	ETTVVRRRGR	23
HLA A*6801	146-154	9	TTVVRRRGR	22.3
HLA B*0702	162-170	9	SPRRRRSQS	21.3
HLA B*0702	170-178	9	SPRRRRSQS	21.3
HLA B*0702	155-163	9	SPRRRTPSP	40.4
HLA B*0801	162-170	9	SPRRRRSQS	39.5
HLA B*0801	170-178	9	SPRRRRSQS	39.5
HLA B*2705	150-159	10	RRRGRSPRRR	49.5
HLA B*2705	164-173	10	RRRRSQSPRR	14.7
HLA B*2705	166-175	10	RRSQSPRRRR	33.9

¹IC₅₀ (nM) < 50 was considered as high affinity. Only IC₅₀ (nM) has been shown in the Table.

Table 2 Deletion of aa 1-11 in preS1 in the different HBV genotypes

Genotype	GenBank No.	Clinic status	Countries/district	Ref.
Human
Genotype C	AF223959	CHB	Vietnam	Erik et al, 2001
	AY217372	CHB	China	Luo et al, 2004
	AB195945	CHB	Japan	Horiike et al, 2007
	EF533714	HCC	China	1Gao et al, 2007
	AY206389	HCC	China	1Lin et al, 2002
	AB014395	HCC	Japan	Takahashik et al, 1998
	AY641563	HCC	South Korea	Song et al, 2005
	D1666	AHB	Japan	Uchida et al, 1995
	X98076	FHB	Switzerland	Pult et al, 1997
Genotype D	AB033559	CHB	Papua New Guinea	Okamoto et al, 1988
	AB119256	CHB	Japan	Michitaka et al, 2006
	M32138	Anti-HBe	France	Tong et al, 1990
	AY902777	FHB	Montana	Garfein et al, 2004
Genotype A	AF297621	FHB	Africa	Owiredu et al, 2001
	U87743	AHB	South Africa	Bowyer et al, 1997
	X69458	AHB	Zimbabwe	Chirara et al, 1994
Ape
Gibbon	AB037928		East Asia	Aiba et al, 2003
Chimpanzee	D00220	HBsAg (+)	London	Vaudin et al, 1988
Gorila	AJ131567	HBsAg (+)	Japan	Grethe et al, 2000
Orangutan	AF193864	CHB	Bornean	Verschoor et al, 2001
Recombination
Human-Gibbon	AB048705	HBsAg (+)	Australian Aborigines	Sugauchi et al, 2001

CHB: Chronic hepatitis B; AHB: Acute hepatitis B; FHB: Fulminant hepatitis B.

¹Sequences were submitted directly to the GenBank.