Polymorphisms of microsomal triglyceride transfer protein in different hepatitis B virus-infected patients

doi:10.3748/wjg.14.5454

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Sep 21, 2008 (publication date) through Nov 29, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 21, 2008; 14(35): 5454-5460
Published online Sep 21, 2008. doi: 10.3748/wjg.14.5454

Table 1 Positions of analyzed SNP and primers used in this study

Genes (Ref.)	SNP	Primers	Sequences (5’-3’)
MTP H297Q	C/G	-1	CAGGTCTTCCAGAGCCAC
rs#2306985[23]		-2	CAGGTCTTCCAGAGCCAG
		-cp	ATTTGTCTGCACTTACAGAAGGA
MTP-493[20]	G/T	-1	ATTTAAACTGTTAATTCATACCACA
		-2	TTTAAACTGTTAATTCATACCACC
		-cp	CTTTAACATTATTTTGAAGTGATTGG

Table 2 General characteristics of 632 subjects

	Self-limited HBV infection (n = 316)	Chronic hepatitis B (n = 316)
	Self-limited HBV infection (n = 316)	With family history (n = 121)	No family history (n = 195)
Male	215	80 (25.3%)	135 (42.7%)
Female	105	41 (13.0%)	60 (19.0%)
Age (yr)	38.28 ± 11.44	36.93 ± 12.28	39.12 ± 10.84
Age range (yr)	9-75	9-69	16-75
ALT level (× ULN)	Normal	3.62 ± 3.48	3.12 ± 2.62
HBV-DNA level (Log)	Undetectable	5.45 ± 2.34

Table 3 Genotype distributions of MTP H297Q and MTP-493G/T n (%)

SNP	Genotype	Self-limited HBV infection (n = 316)	Chronic hepatitis B total (n = 316)	Chronic hepatitis B without family history (n = 195)	χ²test
					SLHBV vs CHB total		SLHBV vs CHB no FH
					Value	P	Value	P
MTP H297Q	CC	33 (10.4)	33 (10.4)	20 (10.3)	0.452	0.798	2.588	0.274
	CG	148 (46.8)	140 (44.3)	78 (40.0)
	GG	135 (42.8)	143 (45.3)	97 (49.7)
MTP-493G/T	GG	232 (73.4)	256 (81.0)	163 (83.6)	8.543	0.015	7.199	0.019¹
	GT	80 (25.3)	52 (16.5)	30 (15.4)
	TT	4 (1.3)	8 (2.5)	2 (1.0)

¹Fisher's exact test (2-Tail). SLHBV: Self-limited HBV infection group; CHB total: Chronic hepatitis B total group; CHB no FH: Chronic hepatitis B without chronic hepatitis B family history group.

Table 4 Allele Distributions of MTP H297Q and MTP-493G/T n (%)

SNP	Allele	Self-Limited HBV infection (n = 632)	Chronic hepatitis B total (n = 632)	Chronic hepatitis B without family history (n = 390)	χ²test and Mantel-Haenszel logit
					SLHBV vs CHB total			SLHBV vs CHB no FH
					P	OR	95% CI	P	OR	95% CI
MTP H297Q	C	214 (33.9)	206 (32.6)	118 (30.3)	0.52	0.903	0.659-1.236	0.232	1.18	0.899-1.549
	G	418 (66.1)	426 (67.4)	272 (69.7)
MTP-493G/T	G	544 (86.1)	564 (89.2)	356 (91.3)	0.023	0.645	0.442-0.940	0.013	0.59	0.389-0.897
	T	88 (13.9)	68 (10.8)	34 (8.7)

SLHBV: Self-limited HBV infection group; CHB total: Chronic hepatitis B total group; CHB no FH: Chronic hepatitis B without chronic hepatitis B family history group.

Citation: Yang ZT, Zhang XX, Kong XF, Zhang DH, Zhang SY, Jiang JH, Gong QM, Jin GD, Lu ZM. Polymorphisms of microsomal triglyceride transfer protein in different hepatitis B virus-infected patients. World J Gastroenterol 2008; 14(35): 5454-5460
URL: https://www.wjgnet.com/1007-9327/full/v14/i35/5454.htm
DOI: https://dx.doi.org/10.3748/wjg.14.5454