Endoscopic findings can predict the efficacy of leukocytapheresis for steroid-naive patients with moderately active ulcerative colitis

Table 1 Steroid-naïve UC patient characteristics (mean ± SD)

Characteristics	Data
Male/Female	11/7
Age (yr)	46.1 ± 18.4
Duration of disease (yr)	6.0 ± 8.5
Clinical course
First attack	4
Relapse-remitting	6
Chronic continuous	8
Extent of disease
Entire	15
Left sided	2
Rectum	1
Endoscopic findings
Erosions	9
Geographic ulcers	6
Deep ulcers	3

Table 2 Comparison of responders and non-responders 8 wk after the last LCAP session (mean ± SD)

	Responders (n = 11)	Non-responders (n = 7)	P
Patient characteristic
Male/Female	7/4	4/3	NS
Age (yr)	39.7 ± 15.9	56.1 ± 17.5	NS
Duration of disease (yr)	5.7 ± 7.7	6.3 ± 9.7	NS
Pre-CAI	9.0 ± 2.0	11.1 ± 0.9	NS
Pre-CRP	1.0 ± 0.8	2.4 ± 2.7	NS
Clinical course
First attack	4	0
Relapse-remitting	6	0
Chronic continuous	1	7	< 0.001
Extent of disease
Entire	8	7
Left sided	2	0
Proctitis	1	0	NS
Endoscopic findings
Erosions	9	0
Geographic ulcers	2	4
Deep ulcers	0	3	< 0.005

LCAP: Leukocytapheresis; CAI: Clinical activity index; CRP: C-reactive protein levels (mg/dL).

Table 3 Comparison of the remission and relapse groups 48 wk after the last LCAP session (mean ± SD)

	Remission (n = 5)	Relapse (n = 6)	P
Patient characteristic
Male/Female	2/3	5/1	NS
Age (yr)	45.4 ± 13.5	35.0 ± 16.1	NS
Duration of disease (yr)	3.5 ± 3.2	7.6 ± 9.6	NS
Pre-CAI	8.8 ± 1.7	9.1 ± 2.2	NS
Post-CAI	0.6 ± 0.4	1.8 ± 1.0	< 0.05
Pre-CRP	1.0 ± 0.9	1.0 ± 0.8	NS
Post-CRP	0.18 ± 0.14	0.32 ± 0.39	NS
Clinical course
First attack	3	1
Relapse-remitting	2	4
Chronic continuous	0	1	NS
Extent of disease
Entire	3	5
Left sided	1	1
Proctitis	1	0	NS
Endoscopic findings
Erosions	4	5
Geographic ulcers	1	1
Deep ulcers	0	0	NS

CAI: Clinical activity index; CRP: C-reactive protein levels (mg/dL).

Table 4 Course of cases whose condition worsened during LCAP

	Case 1	Case 2	Case 3
Additional therapy	PSL	PSL	CsA
		GCV	GCV
Complication	-	CMV	CMV
			Aspiration pneumonitis
Result	Operation	Operation	Dead

PSL: Prednisolone; CsA: Cyclospoline; GCV: Ganciclovir; CMV: Cytomegalovirus.