Clinical Research
Copyright ©2008 The WJG Press and Baishideng.
World J Gastroenterol. Jan 21, 2008; 14(3): 454-462
Published online Jan 21, 2008. doi: 10.3748/wjg.14.454
Table 1 Characteristics of studies included in the analysis
Study IDYearnMean ageSex (male %)Study qualityHerbal medicineType of herbsControlLength (wk)Follow-up (wk)
Gao[10]19921113439LLizhong Huoxie decoctionC.FOryzanol, Nifedipine452
Bensoussan[11]19981164735HIndividualized CHMC.FPlacebo1614
Standard FormulaC.F
Zhao[12]20002333934LTongxie Yaofang modified decoctionC.FSalazosulfapyridine3n.r
Diphenoxylate, Anisodamine, Amitriptyline, Placebo
Lei[13]2000963956LHuatan Liqi Tiaofu decoctionC.FSmecta3n.r
Wang[14]2000963949LGeqin Shujiang Shaocao decoctionC.FSmecta, vitB3n.r
Ye[15]2002803746LXianshi CapsuleC.FDicetel, Smecta8n.r
Deng[16]2002623835LHuanchang decoctionC.FAnisodamine, Oryzanol3-652
Zeng[17]2002983846LCongpi Lunzhi FormulaC.FBacillus Licheniformis6n.r
Ge[18]2002574044LXiangsha Liujunzi decoctionC.FDiazepam, Propantheline, Domperidone2n.r
Zhou[19]2002105n.rn.rLShunji mixtureC.FBitinal4n.r
Sallon[20]20028047.9 ± 2.1138HPadma Lax (Tibetan herbal formula)C.EPlacebo12n.r
46.3 ± 2.93
Ma[21]20032043648LChangkang CapsuleC.FAmitriptyline4n.r
Wang[22]20031045353LWuma Simo decoctionC.FCisapride2n.r
Liu[23]2003773736LGegan Qinlian PelletC.FNifedipine3n.r
Li[24]20031013968LChangning Yin decoctionC.FDiphenoxylate5n.r
Shen[25]20034741.6 ± 12.8157LChangjitai decoctionC.FDicetel8n.r
42.3 ± 14.73
Zhao[26]2004844444LLiyiting decoctionC.FDicetel6n.r
Xiao[27]20041673741LTongxie Yaofang plus sini san decoction (similar with Tongxie Yaofang modified decoction)C.FSalazosulfapyridine Diphenoxylate, Anisodamine, Amitriptyline, Placebo2n.r
Gao[28]2004983635LTongxie yihao capsuleC.FDicetel, Domperidone, Loperamide, Doxepin424
Madisch[29]20042084740H1 STW5C.EPlacebo4n.r
2 STW5-IIC.E
3 Bitter CandytuftM.E
Bo[30]20049238.8 ± 1.7141LJiejing Yiji decoctionC.FCerekinon24
41.3 ± 1.73
Brinkhaus[31]200510647.2 ± 11.7137H1 CurcamaM.EPlacebo18n.r
49.5 ± 14.522 FumitoryM.E
49.0 ± 9.13
Table 2 The type and frequency of adverse events reported in the 22 studies included in the analysis (n = 1279)
Adverse eventsNumber of adverse eventsPercentage95% CI
Distention90.700.32-1.34
Diarrhea80.630.27-1.23
Abdominal pain60.470.17-1.02
Constipation50.390.13-0.91
Dizziness and sleepiness40.310.09-0.80
Headaches40.310.09-0.80
Nausea30.230.05-0.69
Gastrointestinal discomfort10.080.002-0.44
Upper gastrointestinal discomfort10.080.002-0.44
Loss of hair10.080.002-0.44
Pruritus10.080.002-0.44
Paraesthesia10.080.002-0.44
Disturbance10.080.002-0.44
Hoarseness10.080.002-0.44
Shortness of breath and chest pain10.080.002-0.44
Total473.672.73-4.87