Copyright
©2008 The WJG Press and Baishideng.
World J Gastroenterol. Jan 21, 2008; 14(3): 421-427
Published online Jan 21, 2008. doi: 10.3748/wjg.14.421
Published online Jan 21, 2008. doi: 10.3748/wjg.14.421
Table 1 Correlation of integrin β3 mRNA, VEGF protein and MDV with clinicopathological features
Clinicopathological parameters | n | Integrinβ3 mRNA | VEGF | MVD | ||||||||
- | + - +++ | χ2 | P | - | + - +++ | χ2 | P | n/mm2 | t | P | ||
Growth pattern | 118 | 8.42 | < 0.01 | 10.44 | < 0.01 | 3.92 | < 0.01 | |||||
Expansive | 51 | 32 | 19 | 32 | 19 | 49.45 ± 21.72 | ||||||
Infiltrative | 67 | 24 | 43 | 22 | 45 | 64.06 ± 18.76 | ||||||
Histological grade (G) | 6.47 | < 0.05 | 3.49 | 0.062 | 1.25 | > 0.05 | ||||||
G1 + G2 | 70 | 40 | 30 | 37 | 33 | 55.72 ± 21.56 | ||||||
G3 + G4 | 48 | 16 | 32 | 17 | 31 | 60.70 ± 20.73 | ||||||
Invasive depth | 26.60 | < 0.01 | 34.19 | < 0.01 | 6.41 | < 0.01 | ||||||
T1-T2 | 47 | 36 | 11 | 37 | 10 | 44.42 ± 19.96 | ||||||
T3-T4 | 71 | 20 | 51 | 17 | 54 | 66.56 ± 17.23 | ||||||
Vessel invasion | 32.13 | < 0.01 | 39.96 | < 0.01 | 7.96 | < 0.01 | ||||||
No | 29 | 27 | 2 | 28 | 1 | 35.68 ± 14.04 | ||||||
Yes | 89 | 29 | 60 | 26 | 63 | 64.93 ± 18.07 | ||||||
Lymph node metastasis | 31.85 | < 0.01 | 34.71 | < 0.01 | 8.45 | < 0.01 | ||||||
No | 34 | 30 | 4 | 30 | 4 | 37.60 ± 15.73 | ||||||
Yes | 84 | 26 | 58 | 24 | 60 | 66.24 ± 17.24 | ||||||
Distant metastasis | < 0.01 | |||||||||||
No | 63 | 48 | 15 | 50 | 13 | 42.81 ± 17.23 | ||||||
Liver metastasis | 20 | 4 | 16 | 20.48a | < 0.01a | 3 | 17 | 27.25a | < 0.01a | 73.40 ± 8.07 | 7.65a | < 0.01a |
Peritoneal dissemination | 35 | 4 | 31 | 34.72b | < 0.01b | 1 | 34 | 52.77b | < 0.01b | 75.79 ± 9.48 | 10.46b | < 0.01b |
Table 2 Correlation of integrin β3 mRNA, VEGF protein and MVD with survival period
Groups | n | Mean survival period (mo) | t | P | 5-yr survival rate (%) | χ2 | P | |
Integrin β3 mRNA | - | 56 | 38.46 ± 29.20 | 2.27 | < 0.05 | 71.4 (40/56) | 5.60 | < 0.05 |
+ - +++ | 62 | 27.18 ± 24.73 | 11.3 (7/62) | |||||
VEGF | - | 54 | 41.70 ± 30.62 | 3.40 | < 0.01 | 70.4 (16/54) | 6.52 | < 0.05 |
+ - +++ | 64 | 24.80 ± 21.78 | 10.9 (7/64) | |||||
MVD (n/mm2) | < 54.90 | 47 | 44.70 ± 32.05 | 3.84 | < 0.01 | 63.8 (17/47) | 13.85 | < 0.01 |
≥ 54.90 | 71 | 24.48 ± 20.40 | 8.5 (6/71) |
- Citation: Li SG, Ye ZY, Zhao ZS, Tao HQ, Wang YY, Niu CY. Correlation of integrin β3 mRNA and vascular endothelial growth factor protein expression profiles with the clinicopathological features and prognosis of gastric carcinoma. World J Gastroenterol 2008; 14(3): 421-427
- URL: https://www.wjgnet.com/1007-9327/full/v14/i3/421.htm
- DOI: https://dx.doi.org/10.3748/wjg.14.421