Efficacy of 6-mercaptopurine treatment after azathioprine hypersensitivity in inflammatory bowel disease

Table 1 The number of IBD patients in the three groups, according to extents, fistulas and surgeries

	Disease	No. of patients	A	B	C	D	E	F
Group1	UC	7	1	2	4	-	-	-
Group1	CD	2	-	2	-	-	-	-
Group2	CD	8	3	2	2	1	8	16
Group3	UC	8	1	-	7			1
Group3	CD	4	-	3	1	-	4	4
		29	4	9	14	1	12	21

UC-A: Distal; UC-B: Left sided; UC-C: Pancolitis; CD-A: Small bowel only; CD-B: Colon only; CD-C: Small bowel + colon, CD-D: Upper GI + small bowel + colon; CD-E: Number of fistulas; CD-F: Number of surgeries.

Table 2 Changes of CDAI/CAI, CRP, ESR, WBC, PLT variables in the third group (mean ± SD)

Disease	Months	CDAI	CAI	CRP	ESR	WBC	PLT
UC	0	-	7.8 ± 6.3	16 ± 10	30.4 ± 16.2	9.3 ± 3.3	384 ± 175
UC	3	-	6.9 ± 6	8.3 ± 3.5	28.3 ± 16.5	10.3 ± 4.5	336 ± 119
UC	6	-	6.1 ± 6.7	11 ± 19	31.9 ± 32.7	6.8 ± 2	348 ± 197
UC	12	-	1.1 ± 1	4.6 ± 3.5	27 ± 17.2	6.1 ± 2.6	283 ± 87
CD	0	146 ± 128	-	39.8 ± 26.7	41.3 ± 11.6	9.9 ± 2.7	431 ± 136
CD	3	145 ± 124	-	23.3 ± 10.7	29.2 ± 14.1	7 ± 3	332 ± 66
CD	6	167 ± 68	-	21 ± 15	17.6 ± 28.6	9.9 ± 4.2	317 ± 89
CD	12	46 ± 56	-	6 ± 4	18 ± 14.7	6.2 ± 1.3	247 ± 80

Table 3 Significant changes after six and twelve months of 6-MP treatment

Variable	6 mo	12 mo
CDAI	P = 0. 0144 (n = 4)	NS n = 3
CAI	NS n = 8	NS n = 6
Leukocyte	NS	P = 0. 0057
CRP	NS	P = 0. 0206
Serum iron	NS	P = 0. 0459

NS: Not significant.

Table 4 Correlation of activity index numbers with the laboratory variables

Variable	CAI/UC	CDAI/CD
Thrombocyte	P < 0.001	NS
Serum iron	P = 0.006	NS
CRP	P = 0.008	NS
Haematocrit	P = 0.022	NS
Leukocyte	P = 0.071 (BS)	NS
ESR 1st h	P = 0.077 (BS)	NS

NS: Not significant; BS: Borderline significance.

Table 5 Correlation between activity groups and laboratory variables

Variable	1-4 UC (P)	1-4 CD (P)
Fibrinogen	0.0046	NS
Thrombocyte	0.0060	0.0350
CRP	0.0061	NS
Leukocyte	0.0144	0.071 (BS)
Haematocrit	0.0270	NS
Serum iron	0.0808 (BS)	NS

BS: Borderline significance.