Changes of serum p53 antibodies and clinical significance of radiotherapy for esophageal squamous cell carcinoma

Table 1 Sequential change of positive rate of serum p53-Abs in EC patients before and after radiotherapy

Groups	n	-	+	%	χ2	P
Before RT	46	28	18	39.1	0.000	1.0001
20 Gy	46	28	18	39.1	0.187	0.6662
40 Gy	46	30	16	34.8	4.696	0.0303
60 Gy	46	39	7	15.2	6.646	0.0104

¹Before RT vs 20 Gy;

²Before RT vs 40 Gy;

³40 Gy vs 60 Gy;

⁴Before RT vs 60 Gy.

Table 2 Relationship between positive rate of serum p53-Abs and clinical pathophysiological characteristics in EC patients

	n	-	+	Positive (%)	χ2	P
Age (yr)					0.27	0.870
< 50	16	10	6	37.5
≥ 50	30	18	12	40.0
Sex					0.11	0.918
Male	38	23	15	39.5
Female	8	5	3	37.5
TNM stage					6.09	0.014
I+ II	27	21	6	22.2
III + IV	19	8	11	57.9
Histological grade					10.43	0.002
I	15	13	2	13.3
II	17	11	6	35.3
III	14	4	10	71.4
Lymph node metastasis					6.00	0.015
Positive	18	7	11	61.1
Negative	28	21	7	25.0
Size of tumor					2.74	0.102
< 6 cm	32	22	10	31.3
≥ 6 cm	14	6	8	57.1
Site of the tumor					0.02	0.953
Upper thorax	5	3	2	40.0
Middle thorax	21	13	8	38.1
Lower thorax	20	12	8	40.0

TNM: Tumor, nodes and metastasis.

Table 3 Logistic analysis on the relationship between positive rate of serum p53-Abs and clinical pathophysiological characteristics in EC patients

Variables	B	OR	95% CI	P
Age	0.0241	1.0237	0.9583-1.0816	0.4659
Sex	-0.6230	0.5363	0.0863-3.3401	0.5165
TNM stage	1.8389	6.2899	2.4658-3.8954	0.0248
Histological grade	-4.1430	0.0159	0.0039-0.5867	0.0156
Lymph node metastasis	-0.4891	0.5973	0.3327-1.1406	0.1314
Size of tumor	0.6954	1.8924	0.7859-4.5968	0.1602
Site of tumor	-0.0695	0.9530	0.3240-2.6575	0.7986