Effect of fragile histidine triad gene transduction on proliferation and apoptosis of human hepatocellular carcinoma cells

Table 1 Effect of FHIT gene on cell growth and apoptosis in human hepatocellular carcinoma (mean ± SD)

Cell type	G0/G1	S	G2/M	Apoptosis rate (%)
Hep3B	54.36 ± 0.78	17.40 ± 1.32	28.01 ± 1.12	3.78 ± 0.36
Hep3B-C	53.17 ± 0.52	18.23 ± 2.51	28.55 ± 0.55	3.52 ± 0.33
Hep3B-FHITa	72.23 ± 0.84	12.57 ± 0.42	15.12 ± 1.31	9.74 ± 0.43

^aP < 0.05 vs Hep3B or Hep3B-C.

Table 2 Mean tumor formation time and mean tumor weight in nude mice implanted with Hep3B, Hep3B-C or Hep3B-FHIT cells ( n = 5, mean ± SD)

Group	Mean tumor formation time (d)	Mean tumor weight (g)
Hep3B/nude	3.22 ± 0.31	3.66 ± 0.40
Hep3B-C/nude	3.08 ± 0.34	3.94 ± 0.39
Hep3B-FHIT/nude	12.17 ± 1.19	0.60 ± 0.04
Total F value	72.38	168.36
Total P value	0.00	0.00