Abdominal compartment syndrome in patients with severe acute pancreatitis in early stage

Table 1 Etiology of attacks in 74 patients with AP

Etiology of attacks	Number of patients (%)	IAH group No. (%)	Normal IAP group No. (%)
Gallstones	46 (62.16)	26(59.09)	20 (66.67)
Hyperlipidemia	11 (14.86)	7 (15.91)	4 (13.33)
Alcohol	8 (10.81)	5 (11.36)	3 (10.00)
Idiopathic	9 (12.16)	6 (13.64)	3 (10.00)
Total	74	44	30

Table 2 Comparison of clinical data on admission between two groups (mean ± SD)

Clinical data on admission	IAP≥12 mmHg (n = 44)	IAP < 12 mmHg (n = 30)	χ2 or t value	P value
Age (yr)	62.61 ± 11.05	63.57 ± 7.71	-0.41	0.684
Gender (male/female)	23/21	16/14	0.01	0.929
APACHE II score	16.18 ± 3.90	15.70 ± 4.25	0.50	0.616
Ranson score	3.70 ± 0.93	3.47 ± 0.94	1.08	0.285
CTSI	5.25 ± 2.27	5.63 ± 2.01	0.75	0.458

APACHE II score: Acute physiology and chronic health evaluation II score; CTSI: CT scan severity index.

Table 3 Changes in physiological variables after invasive decompressive procedure in patients with ACS (n = 13, mean ± SD)

Variable	Before decompression	After decompression	t value	P value
MAP (mmHg)	53.77 ± 8.98	74.15 ± 6.68	7.23	< 0.001
UBP (mmHg)	36.69 ± 5.33	18.31 ± 3.25	- 8.77	< 0.001
UO (mL/h)	21.76 ± 13.42	85.78 ± 18.46	13.29	< 0.001
CVP (mmHg)	15.01 ± 5.24	13.02 ± 5.01	- 1.97	0.072
BE	-9.31 ± 3.09	-1.69 ± 2.59	6.67	< 0.001
PH	7.28 ± 0.10	7.36 ± 0.06	2.35	0.037
PaO2/FiO2 (mmHg)	129.22 ± 41.30	229.24 ± 63.47	4.33	0.001
PAP (cmH2O)	41.23 ± 12.90	24.46 ± 5.41	- 4.25	0.001
HR (bpm)	132.38 ± 13.68	111.62 ± 12.85	- 5.19	< 0.001
PaCO2 (mmHg)	47.61 ± 11.24	38.63 ± 5.78	- 2.38	0.034
Lactate (mmol/L)	4.48 ± 0.95	2.02 ± 0.80	- 8.11	< 0.001

MAP: Mean arterial pressure; UBP: Urinary bladder pressure; UO: Urine output; CVP: Central venous pressure; BE: Arterial base deficits; pH: Arterial Ph; PaO₂/FiO₂ (MRI): Arterial oxygen partial pressure/fraction of inspired oxygen; PAP: Peak airway pressure; HR: Heart rate; PaCO₂: Arterial carbon dioxide partial pressure; Lactate: Arterial lactic acid.

Table 4 Comparison of complications and outcome between patients with and without ACS

Complications and outcome	ACS (n = 20) (IAP > 20 mmHg)	IAH (n = 24) (12 mmHg ≤IAP ≤20 mmHg)	Normal IAP (n = 30) (IAP < 12 mmHg)	χ2 value	P value
Pancreatic infection (%)	12 (60.00)	2 (8.33)	2 (6.67)	23.84	< 0.001
Septic shock (%)	14 (70.00)	4 (16.67)	2 (6.67)	26.34	< 0.001
MODS (%)	18 (90.00)	10 (41.67)	7 (23.33)	21.85	< 0.001
In-hospital mortality (%)	15 (75.00)	1 (4.17)	1 (3.33)	41.93	< 0.001

MODS: Multiple organ dysfunction syndrome.