Overlap syndromes among autoimmune liver diseases

Table 1 Diagnostic criteria of AIH-PBC overlap syndrome proposed by Chazouillères et al in 1998[5]

AIH (2 out of 3 criteria)

(1) Alanine aminotransferase (ALT) levels > 5 × ULN

(2) Serum immunoglobulin G (IgG) levels > 2 × ULN or a positive test for smooth muscle antibodies (ASMA)

(3) Liver biopsy showing moderate or severe periportal orperiseptal lymphocytic piecemeal necrosis

PBC (2 out of 3 criteria)

(1) Alkaline phosphatase (AP) levels > 2 × or γ-glutamyltranspeptidase (GGT) levels > 5 × ULN

(2) Positive test for antimitochondrial antibodies (AMA)

(3) Liver biopsy specimen showing florid bile duct lesions

ULN: Upper limit of normal value.