Clinical significance of type VI pit pattern subclassification in determining the depth of invasion of colorectal neoplasms

Table 1 Histology/invasion depth of colorectal neoplasm in relation to type V pit pattern subtypes, n (%)

Type V pit pattern subtypes		Histology/invasion depth
		Dysplasia	SM < 1000&mgr;m	1000&mgr;m ≤SM
VI	202 (100)	117 (57.9)	23 (11.4)	62 (30.7)
VN1	70 (100)	0 (0)	3 (4.3)	67 (95.7)

¹Dysplasia. SM < 1000 &mgr;m vs SM ≥ 1000 &mgr;m, P < 0.01. SM: Submucosa.

Table 2 Histology/invasion depth of colorectal neoplasm with type V_I pit pattern in relation to detailed magnifying colonoscopy findings, n (%)

Magnifying		Histology/invasion depth
colonoscopy
finding		Dysplasia	SM < 1000&mgr;m	1000&mgr;m ≤SM
Irregular pit	79 (100)	23 (29.1)	10 (12.7)	46 (58.2)
margins1
Unclear staining	87 (100)	21 (24.1)	16 (18.4)	50 (57.5)
characteristics
of the area
between pits1
Area diameter	138 (100)	65 (47.1)	16 (11.6)	57 (41.3)
of type VI pit
pattern ≥ 5 mm1
High residual	109 (100)	64 (58.7)	16 (14.7)	29 (26.6)
pit density
Wide intervening	138 (100)	81 (58.7)	13 (9.4)	44 (31.9)
membrane
between pits

¹Dysplasia. SM < 1000 &mgr;m vs SM ≥ 1000 &mgr;m, P < 0.01. SM: Submucosa.

Table 3 Results of multivariate logistic regression analysis for predictors of submucosal invasion deeper than 1000 &mgr;m (n = 202)

Magnifying colonoscopy finding	Odds ratio (P value)	Relevant finding
Unclear staining characteristics of the areas between pits	6.24 (< 0.0001)	Clear staining characteristics of the areas between pits
Irregular pit margins	4.89 (< 0.0001)	Regular pit margins
Area diameter of type VI pit pattern ≥ 5 mm	4.14 (0.0132)	Area diameter of type VI pit pattern < 5 mm
High residual pit density	1.51 (0.3335)	Low residual pit density
Wide intervening membrane between pits	1.02 (0.9740)	Narrow intervening membrane between pits

Table 4 Histology/invasion depth of colorectal neoplasm in relation to type V_I pit pattern subclassifications, n (%)

Type VI pit pattern subclassification		Histology/invasion depth
		Dysplasia	SM < 1000&mgr;m	1000&mgr;m ≤SM
Mildly irregular1	104 (100)	89 (85.6)	8 (7.7)	7 (6.7)
Severely irregular	98 (100)	28 (28.6)	15 (15.3)	55 (56.1)

¹Dysplasia. SM < 1000 &mgr;m vs SM ≥ 1000 &mgr;m, P < 0.01. SM: Submucosa.

Table 5 Status of muscularis mucosae in relation to type V pit patterns, n (%)

Type V pit pattern		Status of muscularis mucosae
		Detected	Partially disappeared	Disappeared
VI
Mildly irregular1	104 (100)	97 (93.2)	6 (5.8)	1 (1.0)
Severely irregulara	98 (100)	38 (38.8)	31 (31.6)	29 (29.6)
VNb	67 (100)		8 (11.9)	59 (88.1)

¹Detected vs partially disappeared, disappeared,

^bP < 0.01,

^aP < 0.05.

Table 6 Desmoplastic reaction at the lesion surface in relation to type V pit pattern, n (%)

		Desmoplastic reaction
Type V pit pattern		Absent (-)	Mild to moderate (+)	Severe (++)
VI
Mildly irregular	104 (100)	100 (96.2)	4 (3.8)
Severely irregular	98 (100)	48 (49.0)	29 (29.6)	21 (21.4)
VNb	67 (100)		16 (23.9)	51 (76.1)

^bP < 0.01 (-) vs (+), (++).