Rosiglitazone prevents murine hepatic fibrosis induced by Schistosoma japonicum

doi:10.3748/wjg.14.2905

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May 14, 2008 (publication date) through Nov 5, 2024

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Times Cited (35)

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 14, 2008; 14(18): 2905-2911
Published online May 14, 2008. doi: 10.3748/wjg.14.2905

Table 1 Quantitative analysis of TGF-β1, α-SMA, type I and type III collagen in mouse livers (mean ± SD)

Groups	n	TGF-β1	α-SMA	Type I collagen	Type IIIcollagen
A	10	0.356 ± 0.145	0.602 ± 0.116	0.303 ± 0.117	0.317 ± 0.133
B	10	0.829 ± 0.154^a	0.915 ± 0.172^a	0.654 ± 0.186^a	0.735 ± 0.192^a
C	10	0.655 ± 0.117^a^c	0.902 ± 0.155^a	0.505 ± 0.103^a^c	0.701 ± 0.174^a
D	10	0.603 ± 0.126^a^c	0.732 ± 0.109^a^c^e	0.477 ± 0.132^a^c	0.508 ± 0.127^a^c^e
E	10	0.459 ± 0.107^a^c^e^g	0.689 ± 0.132^c^e	0.382 ± 0.125^c^e^g	0.436 ± 0.112^a^c^e

Compared with group A,

^aP < 0.05; Compared with group B,

^cP < 0.05; Compared with group C,

^eP < 0.05; Compared with group D,

^gP < 0.05.

Table 2 Serum level of TNF-α and IL-6 in mice (mean ± SD)

Groups	n	TNF-α	IL-6
A	10	1.530 ± 0.380	0.094 ± 0.026
B	10	2.892 ± 0.587^a	0.140 ± 0.031^a
C	10	2.346 ± 0.371^a^c	0.137 ± 0.027^a
D	10	2.160 ± 0.395^a^c	0.108 ± 0.021^c^e
E	10	1.613 ± 0.420^c^e^g	0.106 ± 0.021^c^e

Compared with group A,

^aP < 0.05; Compared with group B,

^cP < 0.05; Compared with group C,

^eP < 0.05; Compared with group D,

^gP < 0.05.

Table 3 NF-κB binding activity and the expression of PPARγ-mRNA in mouse livers (mean ± SD)

Groups	n	NF-κB	PPAR-γmRNA
A	10	78.89 ± 18.12	-16.557 ± (-3.022)
B	10	141.11 ± 15.37^a	-27.315 ± (-6.348)^a
C	10	112.89 ± 20.17^a^c	-25.647 ± (-5.694)^a
D	10	108.89 ± 20.47^a^c	-18.217 ± (-4.498)^c^e
E	10	88.89 ± 19.34^c^e^g	-18.212 ± (-3.909)^c^e

Compared with group A,

^aP < 0.05; Compared with group B,

^cP < 0.05; Compared with group C,

^eP < 0.05; Compared with group D,

^gP < 0.05.

Citation: Chen H, He YW, Liu WQ, Zhang JH. Rosiglitazone prevents murine hepatic fibrosis induced by Schistosoma japonicum. World J Gastroenterol 2008; 14(18): 2905-2911
URL: https://www.wjgnet.com/1007-9327/full/v14/i18/2905.htm
DOI: https://dx.doi.org/10.3748/wjg.14.2905