Copyright
©2008 The WJG Press and Baishideng.
World J Gastroenterol. May 7, 2008; 14(17): 2691-2701
Published online May 7, 2008. doi: 10.3748/wjg.14.2691
Published online May 7, 2008. doi: 10.3748/wjg.14.2691
Receptor | Chromosomal location | Angiogenesis | Lymphangiogenesis | |
VEGF | VEGFR1, VEGFR2, NRP1 | 6p23.1 | + | Conflicting data1 |
VEGF-B | VEGFR1, NRP1 | 11q13 | Conflicting data | - |
PIGF | VEGFR1 NRP1, NRP2 | 14q24 | Modest | Not determined |
VEGF-C | VEGFR2 VEGFR3 NRP2 | 4q34 | Modest | + |
VEGF-D | VEGFR2 VEGFR3 | Xp22.31 | Modest | + |
Tumor | Marker | Sample | Cases (n) | LNM | Prognostic impact | Ref. |
Gastric cancer | VEGF-C | Serum | 80 | P = 0.001 | P = 0.001 | 67 |
Esophageal cancer | VEGF-C | Serum | 70 | P = 0.022 | ND | 102 |
Esophageal cancer | VEGF-C | Serum | 73 | ( + )1 | ND | 103 |
Colorectal cancer | VEGF-D | Plasma | 59 | (-) | ND | 38 |
Colorectal cancer | VEGF-C | Plasma | 41 | ( + )2 | ND | 144 |
Colorectal cancer | VEGF-C | Plasma | 120 | (-) | ND | 145 |
VEGF-D | (-) | |||||
Colorectal cancer | VEGF-C | Serum | 66 | ( + ) | ND | 146 |
Breast cancer | VEGF-D | Plasma | 51 | (-) | ND | 46 |
Breast cancer | VEGF-C | Plasma | 122 | (-) | (-) | 47 |
Breast cancer3 | VEGF-D | Plasma | 142 | 48 | ||
Nsc4 lung cancer | VEGF-C | Serum | 92 | P = 0.0260 | ND | 49 |
Nsc lung cancer | VEGF-C | Serum | 78 | P = 0.0004 | ND | 50 |
Nsc lung cancer | VEGF-C | Serum | 116 | P = 0.0007 | ND | 51 |
Cervical cancer | VEGF-C | Serum | 78 | P = 0.0001 | P = 0.0112 | 52 |
Cervical cancer | VEGF-C | Serum | 205 | ( + )2 | ( + )2 | 53 |
Prostate cancer | VEGF-D | Plasma | 30 | P = 0.0043 | ND | 54 |
HNSCC5 | VEGF-C | Plasma | 46 | (-) | (-) | 55 |
- Citation: Tsirlis TD, Papastratis G, Masselou K, Tsigris C, Papachristodoulou A, Kostakis A, Nikiteas NI. Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance? World J Gastroenterol 2008; 14(17): 2691-2701
- URL: https://www.wjgnet.com/1007-9327/full/v14/i17/2691.htm
- DOI: https://dx.doi.org/10.3748/wjg.14.2691