Changes in count and function of splenic lymphocytes from patients with portal hypertension

Table 1 Changes in density of lymphocyte in PH spleen

Group	T lymphocytes				B lymphocytes
	F	MZ	PALS	RP	F	MZ	PALS	RP
PH	89.5 ± 14.7	120.0 ± 14.1	122.9 ± 12.1	12.2 ± 2.9	356.5 ± 31.2	138.0 ± 19.5	113.8 ± 21.6	7.4 ± 1.7
Control	126.5 ± 19.3	140.5 ± 11.6	137.0 ± 6.2	20.45 ± 4.5	418.3 ± 22.4	196.0 ± 22.0	153.8 ± 25.8	12.8 ± 4.6
P value	< 0.01	< 0.05	< 0.05	< 0.01	< 0.01	< 0.01	< 0.05	< 0.01

Table 2 Changes in weight of spleen and lymphocyte count

Group	Relative quantity (× 108)	Weight of spleen (g)	Absolute quantity (× 1011)
PH	0.822 ± 0.157	832.6 ± 278.2	0.685 ± 0.072
Control	1.714 ± 0.254	211.7 ± 85.6	0.366 ± 0.057
P value	< 0.01	< 0.01	< 0.01

Table 3 Changes in proliferative function of lymphocyte in PH spleen

Group	T lymphocyte (ConA 10&mgr;g/L)	B lymphocyte (LPS 20&mgr;g/L)
PH	0.022 ± 0.005	0.034 ± 0.006
Control	0.015 ± 0.003	0.023 ± 0.004
P value	< 0.05	< 0.01