Proliferation of L02 human hepatocytes in tolerized genetically immunocompetent rats

Table 1 Number and area density of PCNA-positive cells at different time points (100 ×, mean ± SD, 10^-4 cells/µm²)

Index	Subgroup		1 wk	2 wk	4 wk	6 wk	8 wk	6 mo
Number density	Human PCNA	H-Rts		0.47 ± 0.08a	1.33 ± 0.34a	0.56 ± 0.38a	0.08 ± 0.03	0.11 ± 0.07
(10-4&mgr;m2/&mgr;m2)		H-2AAF		0.14 ± 0.03	0.43 ± 0.04	0.26 ± 0.08
		H-control		0.10 ± 0.07	0.46 ± 0.04	0.14 ± 0.04
	Nonspecific PCNA	N-Rts	5.53 ± 1.12	5.68 ± 0.89	6.02 ± 0.87	6.78 ± 1.03	5.77 ± 0.68	5.95 ± 1.73
		N-2AAF	6.26 ± 1.07	5.79 ± 0.75	6.32 ± 0.84	7.58 ± 1.17	5.18 ± 1.03
		N-Control	6.20 ± 0.85	5.77 ± 1.18	6.16 ± 1.02	5.46 ± 1.03	6.73 ± 0.58	6.28 ± 0.73
Area density	Human PCNA	H-Rts		2.14 ± 0.22a	7.85 ± 1.46a	3.54 ± 1.63a	0.58 ± 0.72	1.24 ± 0.04
(10-4&mgr;m2/&mgr;m2)		H-2AAF		1.58 ± 0.27	2.36 ± 0.26	1.17 ± 0.22
		H-Control		1.47 ± 0.04	2.94 ± 0.64	2.37 ± 0.48
	Nonspecific PCNA	N-Rts	74.8 ± 1.06	69.3 ± 2.84	45.3 ± 3.38	77.3 ± 4.84	84.7 ± 2.67	73.7 ± 5.38
		N-2AAF	54.6 ± 2.56	49.9 ± 3.37	52.7 ± 4.46	47.5 ± 3.58	51.4 ± 3.27
		N-Control	84.2 ± 6.84	67.5 ± 2.73	66.3 ± 4.48	74.2 ± 5.73	83.3 ± 4.83	66.3 ± 5.74

^aP < 0.05 vs Control.