Clinicopathologic characteristics of intrahepatic cholangiocarcinoma in patients with positive serum a-fetoprotein

Table 1 Clinical features of ICC patients with positive AFP

	AFP
	+ (n = 32)	- (n = 99)	P value
Gender (M/F)	24/8	66/33	NS
Age (yr)	48.7 ± 11.7	54.5 ± 9.9	0.007
HBsAg + (%)	25 (78.1)	38 (38.3)	0.000
Anti-HCV + (%)	0	1 (0.01)	NS
CA19-9 (> 37 U/mL) (%)	10 (31.4)	58 (58.6)	0.007
TBIL (> 17.1 &mgr;mol/L) (%)	17 (53.1)	39 (39.4)	NS
ALT (> 40 IU/L) (%)	16 (50.0)	26 (26.3)	0.012
AST (> 40 IU/L) (%)	14 (43.8)	23 (23.2)	0.025

NS: Not significant; M: Male; F: Female; HBsAg: Hepatitis B surface antigen; HCV: Hepatitis C virus antibody; TBIL: Total bilirubin; AST: Aspartate transaminase; ALT: Alanine transaminase.

Table 2 Pathologic features of ICC patients with and without positive AFP

	AFP
	+ (n = 32)	- (n = 99)	P value
Tumor location (%)			NS
Right lobe	21 (65.6)	57 (57.6)
Left lobe	8 (25.0)	33 (33.3)
Both lobes	3 (9.4)	9 (9.1)
Tumor size (cm)			NS
mean ± SD	7.97 ± 4.12	6.83 ± 2.98
≤ 3 (%)	2 (0.6)	9 (0.9)
Tumor number (%)			NS
Single	25 (78.2)	62 (62.7)
≥ 2	7 (21.8)	37 (37.3)
Liver cirrhosis (%)	13 (40.6)	22 (22.2)	0.041
Capsule formation (%)	8 (25.0)	15 (15.2)	NS
Histological grades (%)			NS
Well- Moderately	21 (65.6)	68 (68.6)
Poorly	11 (34.4)	31 (31.4)
Lymph node metastasis (%)	5 (15.6)	35 (35.4)	0.035
Portal invasion (%)	1 (3.1)	5 (5.1)	NS
Microvascular invasion (%)	18 (56.2)	62 (62.6)	NS
Immunohistochemical examinations			NS
Hepatocyte paraffin	1	0	0
Cytokeratin 19 (%)	32 (100)	99 (100)

NS: Not significant.