Effect of Oxymatrine on the TGFbeta-Smad signaling pathway in rats with CCl4-induced hepatic fibrosis

Table 1 Semi-quantitative scores of hepatic fibrosis staging

Score	Pathological description	Stage
0	No fibrosis	No fibrosis
1	Slight fibrosis	Periportal fibrosis
2	Medium fibrosis	Enlarged periportal fibrosis
3	Severe fibrosis	Bridging fibrosis
4	Cirrhosis	Cirrhosis

Table 2 Serum TGFβ1 concentration and collagen area in liver tissues (mean ± SD)

Group	TGFβ1 (&mgr;g/L)	Collagen area (&mgr;m2)
Control	1.34 ± 0.25b	56.12 ± 21.45a
Model	3.59 ± 1.23	290.86 ± 89.37
Treat	1.82 ± 0.61a	94.41 ± 37.26a

^aP < 0.05,

^bP < 0.01 vs model group.

Table 3 Liver histopathological semi-quantitative scores (According to HAI)

Group	n	Scores					Staging scores
		0	+1	+2	+3	+4
Control	20	20	0	0	0	0	0b
Model	30	0	0	2	3	25	3.76 ± 0.68
Treat	35	0	2	18	13	2	2.43 ± 0.47a

^aP < 0.05,

^bP < 0.01 vs model group.

Table 4 Expression of Smad 3, Smad 7 and CBP in liver tissues

Group	Smad 7 (IH, %)	mRNA (A)
		Smad 7	Smad 3	CBP
Control	0b	12:00 AM	0b	0b
Model	0.019 ± 0.002	0.074 ± 0.012	0.167 ± 0.092	0.235 ± 0.025
Treat	0.043 ± 0.009a	0.175 ± 0.065b	0.034 ± 0.090a	0.235 ± 0.025

^aP < 0.05,

^bP < 0.01 vs model group.