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©2008 The WJG Press and Baishideng.
World J Gastroenterol. Apr 7, 2008; 14(13): 2029-2036
Published online Apr 7, 2008. doi: 10.3748/wjg.14.2029
Published online Apr 7, 2008. doi: 10.3748/wjg.14.2029
Placebo (n = 16) | LGG (n = 13) | Bb12 (n = 16) | PJS (n = 17) | P value1 | |
Leukocytes | 4.90 (3.90-7.05) | 5.20 (4.90-6.40) | 5.25 (4.60-6.00) | 4.90 (4.35 -5.70) | 0.55 |
Monocytes | 5.00 (4.25-6.75) | 5.00 (5.00-6.00) | 6.00 (5.00-6.00) | 6.00 (4.50-6.50) | 0.84 |
Neutrophils | 2.05 (1.67-3.72) | 3.10 (2.50-3.30) | 2.95 (2.12-3.47) | 3.10 (2.15-3.45) | 0.39 |
Basophils | 0.05 (0.00-0.10) | 0.10 (0.00-0.10) | 0.05 (0.00-0.10) | 0.00 (0.00-0.10) | 0.73 |
Eosinophils | 4.00 (3.00-5.75) | 3.00 (2.00-6.00) | 3.00 (2.25-4.75) | 2.00 (1.50-3.00) | 0.077 |
Lymphocytes | 38.0 (33.5-48.7) | 35.0 (31.5-37.5) | 34.0 (30.0-40.5) | 31.0 (26.0-40.5) | 0.24 |
IgM | 1.28 (0.97-1.65) | 0.87 (0.69-1.32) | 1.10 (0.73-1.66) | 1.44 (0.80-1.77) | 0.31 |
IgG | 10.7 (9.5-12.2) | 10.3 (9.3-11.7) | 10.6 (9.1-12.1) | 10.4 (8.4-11.7) | 0.72 |
IgA | 2.65 (2.45-3.21) | 2.42 (2.04-3.44) | 2.20 (1.73-2.94) | 2.44 (1.53-2.85) | 0.22 |
sIgA | 0.23 (0.15- 0.34) | 0.27 (0.14-0.42) | 0.40 (0.27-0.88) | 0.28 (0.17-0.49) | 0.065 |
Placebo (n = 16) | LGG (n = 13) | Bb12 (n = 16) | PJS (n = 17) | P value1 | Localization | |
TNF-α | ||||||
Streptococcus | 703 (-315-1784) | -1883 (-2389-540) | -645 (-1843-1403) | 315 (-1045-1460) | 0.025 | LGG vs placebo |
Influenza | 31 (-3-66) | 6 (-83-84) | -27 (-101-37) | 29 (-39-83) | 0.32 | |
LPS | 11 (-16-38) | -15 (-31-10) | 14 (-36-48) | -6 (-78-36) | 0.53 | |
IFN-γ | ||||||
Streptococcus | -19 (-221-97) | -10 (-227-284) | 71 (-161-360) | -23 (-223-155) | 0.6 | |
Influenza | 117 (29-284) | -72 (-221-194) | -7 (-436-189) | 102 (-59-218) | 0.25 | |
LPS | NA | NA | NA | NA | ||
IL-1β | ||||||
Streptococcus | 2308 (45-5222) | -1324 (-5609-352) | 444 (-6152-5000) | 649 (-3412-3747) | 0.49 | |
Influenza | 166 (13-478) | 83 (-183-273) | -15 (-817-170 ) | 156 (-75-791) | 0.69 | |
LPS | 67 (-29-138) | 5 (-147-114) | 51 (-40-122) | 17 (-43-199) | 0.66 | |
IL-2 | ||||||
Streptococcus | 5 (-23-79) | -46 (-176-0) | 1 (-135-97) | 39 (-105-213) | 0.33 | |
Influenza | 25 (-18-42) | 14 (-51-62) | -55 (-162-14) | 10 (-27-39) | < 0.001 | Bb12 vs others |
LPS | 2 (-18-35) | 27 (-25-57) | 1 (-42-51) | 6 (-35-25) | 0.54 | |
IL-6 | ||||||
Streptococcus | 793 (-691-4829) | -379 (-3955-397) | 205 (-2757-1553) | 175 (-4344-909) | 0.82 | |
Influenza | 1530 (166-4632) | 1288 (-4329-4073) | 550 (-7178-1905) | 1644 (-327-3344) | 0.74 | |
LPS | 947 (-418-2527) | -2189 (-3675-4053) | 329 (-1949-3950) | 639 (-1217-1607) | 0.13 | |
IL-8 | ||||||
Streptococcus | 240 (-1585-3914) | 34 (-3066-3143) | 400 (-3638-2891) | 132 (-2667-2976) | 0.96 | |
Influenza | -455 (-1966-1670) | -193 (-2953-1520) | -1675 (-4245 to -601) | -1148 (-2550-1707) | 0.31 | |
LPS | -742 (-3384-180) | -149 (-1608-1517) | -334 (-2692-739) | -1111 (-2457-836) | 0.78 | |
IL-10 | ||||||
Streptococcus | 907 (263-2149) | -4 (-881-2420) | 452 (-2982-1735) | 226 (-86-950) | 0.29 | |
Influenza | 95 (48-284) | -57 (-159-233) | 4 (-301-130) | 95 (13-350) | 0.25 | |
LPS | 381 (19-602) | 78 (-298-656) | 347 (-403-796) | 187 (28-1440) | 0.51 | |
IL-12 | ||||||
Streptococcus | 26 (-18-75) | -32 (-99-36) | 22 (-36-67) | 35 (-73-172) | 0.46 | |
Influenza | 0 (-4-16) | 7 (-9-30) | 8 (-19-51) | 5 (-25-37) | 0.88 | |
LPS | 15 (1-36) | 3 (-7-28) | 0 (-6-29) | 0 (-62-20) | 0.23 |
Strain | Fecal samples | |||||||
Placebo (n = 16) | LGG (n = 13) | Bb12 (n = 16) | PJS (n = 17) | |||||
Baseline | After intervention | Baseline | After intervention | Baseline | After intervention | Baseline | After intervention | |
L. rhamnosus GG | ||||||||
Number of subjects1 | 7 | 10 | 7 | 13 | 10 | 5 | 6 | 9 |
Mean (SD)2 | 4.7 (1.2) | 5.1 (1.1) | 5.1 (1.4) | 8.6 (0.6) | 5.2 (1.3) | 4.6 (1.5) | 4.5 (1.2) | 5.0 (1.4) |
B. animalis ssp. lactis Bb12 | ||||||||
Number of subjects1 | 6 | 5 | 5 | 2 | 7 | 16 | 2 | 4 |
Mean (SD)2 | 5.4 (1.6) | 5.3 (1.7) | 5.3 (1.4) | 4.9 (1.3) | 5.4 (1.6) | 8.6 (0.5) | 4.7 (1.1) | 5.1 (1.6) |
P. freudenreichii ssp. shermanii JS | ||||||||
Number of subjects1 | 4 | 2 | 2 | 2 | 4 | 4 | 1 | 16 |
Mean (SD)2 | 4.5 (1.4) | 4.0 (0.7) | 4.1 (0.8) | 4.0 (0.6) | 4.4 (1.6) | 4.2 (0.9) | 3.8 (0.3) | 8.3 (1.0) |
- Citation: Kekkonen RA, Lummela N, Karjalainen H, Latvala S, Tynkkynen S, Järvenpää S, Kautiainen H, Julkunen I, Vapaatalo H, Korpela R. Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults. World J Gastroenterol 2008; 14(13): 2029-2036
- URL: https://www.wjgnet.com/1007-9327/full/v14/i13/2029.htm
- DOI: https://dx.doi.org/10.3748/wjg.14.2029