Relationship between cell adhesion molecules expression and the biological behavior of gastric carcinoma

Table 1 Correlation between expressions of syndecan-1, E-cadherin and integrin β3 and pathological parameters in 118 gastric carcinoma patients

Variable	(n)	Syndecan-1 expression				E-cadherin expression				Integrinβ3 expression
		Low	High	χ2	P	Low	High	χ2	P	Low	High	χ2	P
Growth mode of tumors
Invasion	67	48	19	12.47	0.000	49	18	15.27	0.000	27	40	5.836	0.016
Expansion	51	20	31			19	32			32	19
Histologic differentiations
Well/moderate	70	37	33	1.60	0.205	37	33	1.60	0.205	36	34	0.140	0.708
Poor	48	31	17			31	17			23	25
Depth of invasion
T1-T2	47	12	35	32.95	0.000	13	34	28.73	0.000	38	9	29.74	0.000
T3-T4	71	56	15			55	16			21	50
Vascular invasion
Negative	29	1	28	46.22	0.000	2	27	40.52	0.000	28	1	33.33	0.000
Positive	89	67	22			66	23			31	58
Lymphatic metastasis
Negative	35	4	31	43.49	0.000	5	30	38.28	0.000	31	4	29.61	0.000
Positive	83	64	19			63	20			28	55
Distant metastasis
Negative	63	15	48	63.30	0.000	17	46	51.98	0.000	49	14	41.72	0.000
Positive	55	53	2			51	4			10	45

Table 2 Relationship among the expressions of syndecan-1, E-cadherin and integrin β3 in gastric carcinoma

Groups	Syndecan-1			r	P	E-cadherin			r	P
	-	+	++			-	+	++
Syndecan-1
-	43					38	4	1
+		25				11	12	2
++			50			3	0	47
E-cadherin				0.837	0
-	38	11	3			52
+	4	12	0				16
++	1	2	47					50
Integrin β3				-0.792	0				-0.666	0
-	2	6	48			9	1	46
+	1	1	1			2	0	1
++	18	8	1			19	8	2
+++	22	10	0			22	7	1

Table 3 Relationship between the expressions of syndecan-1, E-cadherin and integrin β3 and the prognosis of gastric carcinoma patients

Groups	n	Mean survival time (mo)	5-yr survival rate (%)	χ2	P
Syndecan-1 expression
Low expression	68	32.10 ± 4.16	12.80	53.13	0
High expression	50	123.80 ± 5.56	91.66
E-cadherin expression
Low expression	68	33.69 ± 4.33	12.80	43.36	0
High expression	50	119.78 ± 5.87	93.59
Integrin β3 expression
Low expression	59	103.30 ± 7.73	72.75	35.11	0
High expression	59	33.12 ± 4.64	13.85