Current view of the immunopathogenesis in inflammatory bowel disease and its implications for therapy

Table 1 IBD immunopathogenesis

Immune dysregulation

Cytokines

Epiteliol barrier function

Oral tolerance

Reactive oxygen species (ROS)

Antioxidant defence system

Table 2 Medical management based on pathogenesis

Dietary nutrients

Polyunsaturated fatty acids (PUFAs)

Fiber

Probiotics

Prebiotics

Flavonoids

Antagonist platelet-activating factor (PAFs)

Biological therapies

Anti-inflammatory/Immunosuppressive

Immunomodulators

Generation regulatory T cells/Activation effector T cells

Inhibition of recruitment, migration, adhesion molecules

Epithelial repair/Restitution barrier function

Induction apoptosis

Autologous hematopoietic stem cell transplant