Ai KX, Lu LY, Huang XY, Chen W, Zhang HZ. Prognostic significance of S100A4 and vascular endothelial growth factor expression in pancreatic cancer. World J Gastroenterol 2008; 14(12): 1931-1935 [PMID: 18350635 DOI: 10.3748/wjg.14.1931]
Corresponding Author of This Article
Kai-Xing Ai, Department of General Surgery, 6th Affiliated Hospital of Shanghai Jiaotong University, Shanghai 200233, China. akxing8258@sina.com
Article-Type of This Article
Rapid Communication
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Table 3 Correlation between VEGF expression and clinicopathological parameters in pancreatic cancer, n (%)
Clinicopathological parameters
Cases (n)
VEGF expression
P value
Positive
Negative
Age (yr)
≥ 70
24
17 (70.8)
7 (29.2)
< 70
38
20 (52.6)
18 (47.4)
> 0.05
Gender
Male
36
24 (66.7)
12 (33.3)
Female
26
13 (50)
13 (50)
> 0.05
Differentiation
Well
17
10 (58.8)
7 (41.2)
Moderately
15
8 (53.3)
7 (46.7)
Poorly
30
19 (63.3)
11 (36.7)
> 0.05
Tumor size (cm)
< 2.0
3
2 (66.7)
1 (33.3)
2.0-4.0
38
21 (55.3)
17 (44.7)
> 4.0
21
14 (66.7)
7 (33.3)
> 0.05
Lymph node metastasis
(-)
13
7 (53.8)
6 (46.2)
(+)
49
30 (61.2)
19 (38.8)
> 0.05
Distant metastasis
(-)
39
24 (61.5)
15 (38.5)
(+)
23
13 (56.5)
10 (43.5)
> 0.05
NM stage
I + II
30
17 (56.7)
13 (43.3)
III + IV
32
20 (62.5)
12 (37.5)
> 0.05
Table 4 Cox multivariate regression analysis of clinicopathological features as a prognostic predictor
B
SE
Wald
df
P value
OR (95% CI)
Distant metastasis
1.101
0.345
10.163
1
0.001
3.006 (1.528, 5.914)
S100A4
0.893
0.338
6.989
1
0.008
2.443 (1.260, 4.736)
VEGF
0.821
0.340
5.815
1
0.016
2.272 (1.166, 4.426)
Citation: Ai KX, Lu LY, Huang XY, Chen W, Zhang HZ. Prognostic significance of S100A4 and vascular endothelial growth factor expression in pancreatic cancer. World J Gastroenterol 2008; 14(12): 1931-1935