Cost-effectiveness analysis of early veno-venous hemofiltration for severe acute pancreatitis in China

Table 1 Outcomes based on a previous systematic review[14]

Outcomes	CVVH /LVVH only		SVVH only		SVVH plus PD		Control
Overall mortality rate (%, ratio)	0.149	40/47	0.058	129/137	0.147	29/34	0.179	322/392
Survival rate (%)	0.851		0.942		0.853		0.821
Overall complications rate (%, ratio)	0.267	4/15	0.208	15/72	0.157	8/51	0.412	120/291
Complications prevention rate (%)	0.733		0.792		0.843		0.588
Surgery rate (%, ratio)	0.075	3/40	0.016	1/62	0.082	5/61	0.294	58/197
Surgery preservation rate (%)	0.925		0.984		0.918		0.706

CVVH: Continuous veno-venous hemofiltration; LVVH: Long-term veno-venous hemofiltration; SVVH: Short-term veno-venous hemofiltration; PD: Peritoneal dialysis.

Table 2 Total hospitalization costs obtained from published Chinese articles (10 000 RMB)

Study	Refence	CVVH/LVVH only			SVVH only			SVVH plus PD			Control
		Mean	SD	n	Mean	SD	n	Mean	SD	n	Mean	SD	n
Mao EQ 1999	[23]	-	-	-	5.32	1.6	10	-	-	-	8.91	2.5	10
Mao EQ 2003	[19]	13.7	10.5	16	5.66	5.64	20	-	-	-	-	-	-
Feng GH 2004	[21]	-	-	-	-	-	-	6.1	1.9	25	9.4	3.1	15
Yang FF 2005	[24]	-	-	-	-	-	-	5.8	2.2	36	10.2	4.3	64
Zhang T 2005	[25]	-	-	-	3.29	1.279	38	-	-	-	6.884	4.868	71

CVVH: Continuous veno-venous hemofiltration; LVVH: Long-term veno-venous hemofiltration; SVVH: Short-term veno-venous hemofiltration; PD: Peritoneal dialysis.

Table 3 Weighted total hospitalization costs

Modalities	Cost (C)1			Incremental cost (ΔC)2
	WM	Max	Min	WMD
CVVH/LVVH only	$18 826 (144 051 RMB)	$33 254 (254 455 RMB)	$4397 (33 647 RMB)	$13 017 (99 602 RMB)
SVVH only	$5809 (44 449 RMB)	$9359 (71 613 RMB)	$2259 (17 286 RMB)
SVVH plus PD	$7868 (60 205 RMB)	$10 622 (81 279 RMB)	$5114 (39 130 RMB)	$2059 (15 756 RMB)
Control	$11 317 (86 597 RMB)	$17 006 (130 128 RMB)	$5628 (43 066 RMB)	$5508 (42 148 RMB)

¹All the costs were converted to 2005 price before combination.

²SVVH only, the least costly arm, was selected as common baseline for other arms to reference to. WM: Weighted mean; WMD: Weighted mean difference; CVVH: Continuous veno-venous hemofiltration; LVVH: Long-term veno-venous hemofiltration; SVVH: Short-term veno-venous hemofiltration; PD: Peritoneal dialysis.

Table 4 Results of cost-effectiveness analyses ($/%)

Subsets	CVVH/LVVH only	SVVH only	SVVH plus PD	Control
C/Survival	$22 122	$6167	$9224	$13 785
C/Complication prevention	$25 683	$7334	$9333	$19 247
C/Surgery preservation	$20 352	$5903	$8571	$16 030
ΔC/ΔSurvival	Dominated	-	Dominated	Dominated
ΔC/ΔComplication prévention	Dominated	-	$40 375	Dominated
ΔC/ΔSurgery preservation	Dominated	-	Dominated	Dominated

CVVH: Continuous veno-venous hemofiltration; LVVH: Long-term veno-venous hemofiltration; SVVH: Short-term veno-venous hemofiltration. SVVH only, the least costly arm, was selected as common baseline for other arms to reference to; PD: Peritoneal dialysis.