KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro

Table 1 Effect of KN-93 and KN-92 on cell proliferation in human hepatic stellate cells (LX-2) after 24 incubation (n = 3, mean ± SD)

	Cell proliferation (% of control)
Concentration	KN-93	KN-92
Control	100.00 ± 3.32	100.00 ± 3.32
5 μmol/L	81.76 ± 2.58a	96.63 ± 2.69
10 μmol/L	60.30 ± 2.59b	96.24 ± 3.14
25 μmol/L	33.42 ± 3.07b	95.61 ± 2.81
50 μmol/L	27.15 ± 2.86b	96.59 ± 2.44

^aP < 0.05,

^bP < 0.01 vs control group.

Table 2 Effect of 10 μmol/L KN-93 and KN-92 on cell proliferation in human hepatic stellate cells (LX-2) after treatment for various periods of time (n = 3, mean ± SD)

	Cell proliferation (% of control)
Time of treatment	KN-93	KN-92
Control	100.00 ± 2.86	100.00 ± 3.32
4 h	99.56 ± 3.53	97.12 ± 2.97
8 h	78.27 ± 2.92b	96.95 ± 2.56
16 h	52.26 ± 2.90b	98.34 ± 3.18
24 h	30.54 ± 2.82b	96.53 ± 2.67
48 h	11.48 ± 3.16b	97.12 ± 3.09

^bP < 0.01 vs control group.