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Copyright ©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Feb 21, 2007; 13(7): 1112-1118
Published online Feb 21, 2007. doi: 10.3748/wjg.v13.i7.1112
Table 1 Effect of aqueous anise suspension on gastric lesions induced by various necrotizing agents (mean  ± SD)
GroupDose Ulcer index
serialTreatment(mg/kg, i.g.)80% EtOH0.2 mol/L NaOH25% NaCl
1Control (distilled water)-7.16 ± 0.408.00 ± 0.07.66 ± 0.33
2Pimpinella anisum2506.00 ± 0.51b4.66 ± 0.80d6.00 ± 0.44d
3Pimpinella anisum5004.00 ± 0.44d3.66 ± 0.66d4.00 ± 0.51d
Table 2 Effect of aqueous anise suspension on ethanol-induced histopathological changes in rat stomach
GroupserialTreatment and dose(mg/kg, body weight/day)Histopathological changes
CongestionHaemorrhageEdemaNecrosisInflammatorychangesDysplasticchangesErosionsUlceration
1Control (distilled water)--------
(1 mL/rat)
2Ethanol, 80% (1 mL/rat)+++++++++++++++
3Pimpinella anisum+++---+-
(250) + ethanol, 80% (1 mL/rat)
4Pimpinella anisum+++---+-
(500) + ethanol, 80% (1 mL/rat)
Table 3 Effect of aqueous anise suspension on indomethacin-induced gastric mucosal lesions (mean  ±  SD)
GroupserialTreatmentAnimals(n)Dose(mg/kg, i.g.)Ulcer index
1Control (indo only)6-32.16 ± 5.22
2Pimpinella anisum + indo62509.66 ± 1.96d
3Pimpinella anisum + indo65006.00 ± 2.68d
Table 4 Effect of aqueous anise suspension on the levels of non-protein sulfhydryles (NP-SH) in glandular stomach of rats treated with 80% ethanol (mean  ±  SD)
GroupTreatment and doseNP-SH concentration
serial(mg/kg, body weight)(μmol/100 mg wet tissue)
1Control (distilled water, 1 mL/rat)11.70 ± 0.86
2Control (80% ethanol, 1 mL/rat)6.31 ± 0.23b
3Pimpinella anisum (250) + 80% ethanol (1 mL/rat)6.71 ± 0.33
4Pimpinella anisum (500) + 80% ethanol (1 mL/rat)7.68 ± 0.37a
Table 5 Effect of anise suspension on gastric secretion, acidity and gastric lesion index in pylorus-ligated Shay rats (mean  ±  SD)
Group serialTreatmentDose (mg/kg, i.g)Volume of gastric content (mL)Titratable acid (mEq/L)Ulcer index
1Control (distilled water)-7.83 ± 0.38127.21 ± 2.640.66 ± 0.21
2Pimpinella anisum2503.00 ± 0.51b109.33 ± 4.64d0.00d
3Pimpinella anisum5000.33 ± 0.33d108.33 ± 5.00d0.00d
Table 6 Effect of aqueous anise suspension on ethanol-induced gastric wall mucus concentration changes (mean  ±  SD)
GroupserialTreatmentDosage(mg/kg,i.g.)Gastric wall mucus (μg Alcianblue of wet glandular tissue)
1Control (distilled water)-474.98 ± 13.86
280% ethanol only-307.92 ± 10.69d
3Pimpinella anisum 80% ethanol250372.75 ± 20.87a
4Pimpinella anisum 80% ethanol500391.60 ± 20.19b