Decreased fragile histidine triad expression in colorectal cancer and its association with apoptosis inhibition

Table 1 Expression of FHIT and clinical or pathological factors

	n	FHIT expression		χ2	P
		Positive	Negative
Age
< 60	34	16	18	0.16	0.901
≥ 60	46	21	25
Sex
M	42	19	23	0.04	0.849
F	38	18	20
Differentiated
Well	16	12	4	4.84	0.028
Moderately	44	20	24
Poorly	20	5	15
Dukes
A, B	45	27	18	7.82	0.005
C, D	35	10	25
Lymph node metastasis
Positive	16	11	5	4.07	0.006
Negative	64	26	38
Survival
≥ 5 yr	35	23	12	5.77	0.016
< 5 yr	18	5	13

Table 2 Relationship between FHIT expression and apoptosis index (AI) in human CRC

FHIT	n	AI
-	11	0.56 ± 0.10
+/-	15	1.07 ± 0.16
+	17	2.99 ± 0.32
++	37	5.41 ± 0.23

Table 3 Expression of Bax, Bcl-2, survivin and correlation with FHIT alteration

		n	FHIT expression		χ2	P
			Positive	Negative
Bax	+	62	25	37	3.89	0.048
	-	18	12	6
Bcl-2	+	58	32	26	6.75	0.009
	-	22	5	17
Survivin	+	41	11	30	12.76	0
	-	39	26	13