Serum γ-glutamyltransferase, alanine aminotransferase, and aspartate aminotransferase activity in Iranian healthy blood donor men

Table 1 AST tertiles according to characteristics of the study population

	AST
Variable	< 21	21-25	> 25	P
Age (mean ± SD), yr	42.1 ± 11.4	40.9 ± 11.2	39.5 ± 10.2	0.020 (group 1 vs group 3)
Body weight (mean ± SD), km	80.6 ± 11.9	82.1 ± 12.8	85.7 ± 13.4	0.000 (group 1, 2 vs group 3)
Height (mean ± SD), cm	174.4 ± 6.9	174.9 ± 6.4	175.3 ± 6.8	0.232
Body mass index (BMI) (mean ± SD)	26.6 ± 3.7	26.9 ± 3.9	27.9 ± 4.3	0.000 (group 1, 2 vs group 3)
Waist circumference (mean ± SD), cm	94.3 ± 8.6	95.5 ± 9.7	97.3 ± 9.7	0.000 (group 1, 2 vs group 3)
Hip circumference (mean ± SD), cm	100.7 ± 8.2	101.5 ± 9.4	103 ± 9.1	0.001 (group 1, 2 vs group 3)
Waist to hip ratio (WHR) (mean ± SD)	0.94 ± 0.04	0.94 ± 0.05	0.94 ± 0.05	0.449
Diabetes mellitus (% positive)	2.7	1.3	1.0	0.226
Family history of diabetes (% positive)	23.3	18.8	18.6	0.271
Family history of liver disease (% positive)	0.3	1.6	1.3	0.276
Hypertension (% positive)	3.7	2.6	2.3	0.574
Dyslipidemia (% positive)	6.3	4.9	8.1	0.262
Smoking habit (% positive)	24.0	21.7	19.7	0.435

Table 2 ALT tertiles according to characteristics of the study population

	ALT
Variable	< 22	22-34	> 34	P
Age (mean ± SD), yr	42.1 ± 11.9	41.5 ± 10.9	38.9 ± 9.9	0.001 (group 1, 2 vs group 3)
Body weight (mean ± SD), kg	79.0 ± 11.5	83.0 ± 11.4	86.5 ± 14.4	0.000 (all of groups)
Height (mean ± SD), cm	174.45 ± 6.76	174.67 ± 6.69	175.4 ± 6.6	0.173
Body mass index (BMI) (mean ± SD)	25.94 ± 3.4	27.29 ± 3.6	28.1 ± 4.6	0.000 (all of groups)
Waist circumference (mean ± SD), cm	93.2 ± 9.5	95.7 ± 8.6	98.1 ± 9.5	0.000 (all of groups)
Hip circumference (mean ± SD), cm	99.5 ± 9.0	102.0 ± 8.2	104.1 ± 9.2	0.001 (all of groups)
Waist to hip ratio (WHR) (mean ± SD)	0.94 ± 0.04	0.94 ± 0.05	0.94 ± 0.05	0.152
Diabetes mellitus (% positive)	2.0	1.0	1.9	0.571
Family history of diabetes (% positive)	20.6	21.8	18.2	0.538
Family history of liver disease (% positive)	0.3	1.3	1.6	0.268
Hypertension (% positive)	3.6	2.4	2.6	0.621
Dyslipidemia (% positive)	4.9	7.4	7.1	0.402
Smoking habit (% positive)	21.64	23.57	20.2	0.602

Table 3 GGT tertiles according to characteristics of the study population

	GGT
Variable	< 15	15-25	> 25	P
Age (mean ± SD), yr	38.8 ± 11.4	42.4 ± 11.2	41.3 ± 10.1	0.000 (group 1 vs group 2, 3)
Body weight (mean ± SD), kg	79.1 ± 11.2	83.8 ± 12.6	85.7 ± 13.9	0.000 (group 1 vs group 2, 3)
Height (mean ±SD), cm	174.6 ± 6.5	174.9 ± 7.0	175.1 ± 6.6	0.675
Body mass index (BMI) (mean ± SD)	25.9 ± 3.3	27.6 ± 4.3	27.9 ± 4.0	0.000 (group 1 vs group 2, 3)
Waist circumference (mean ± SD), cm	92.9 ± 9.1	96.5 ± 9.5	97.8 ± 8.9	0.000 (group 1 vs group 2, 3)
Hip circumference (mean ± SD), cm	99.2 ± 8.9	102.8 ± 9.0	103.7 ± 8.5	0.001 (group 1 vs group 2, 3)
Waist to hip ratio (WHR) (mean ± SD)	0.94 ± 0.04	0.94 ± 0.04	0.94 ± 0.05	0.103
Diabetes mellitus (% positive)	0.6	2.0	2.3	0.217
Family history of diabetes (% positive)	19.1	22.1	19.5	0.608
Family history of liver disease (% positive)	0.0	1.0	2.3	0.023
Hypertension (% positive)	2.2	2.7	3.6	0.582
Dyslipidemia (% positive)	5.1	7.1	7.2	0.486
Smoking habit (% positive)	19.49	23.29	22.7	0.471

Table 4 Correlation of the study population characteristics with AST, ALT, and GGT levels

Dependent variable	Independent variable	Coefficients		P
		B	Std. Error
AST	Age	-0.125	0.039	0.002
	Family history of liver disease	15.763	4.029	0.000
	Smoking habit	-1.874	1.056	0.076
ALT	Age	-0.317	0.071	0.000
	Family history of liver disease	32.345	7.258	0.000
	Dyslipidemia	6.988	3.363	0.038
GGT	Family history of liver disease	24.415	5.791	0.000