Antidiabetic effects of chitooligosaccharides on pancreatic islet cells in streptozotocin-induced diabetic rats

Table 1 Effect of COS on changes of plasma glucose in glucose tolerance test and AUC after 60 d (n = 9, mean ± SD)

Group	Concentration	Plasma glucose tolerance/mmol/L				AUC	AUC
	mg/kg	0 h	0.5 h	1 h	2 h	mmol/L	%
Control	-	2.75 ± 1.14b	6.27 ± 1.99b	5.78 ± 1.99b	5.34 ± 1.06b	21.66 ± 6.18b	17.69
Met	200	4.42 ± 1.72	28.01 ± 4.71	32.98 ± 2.98	25.64 ± 4.26	105.33 ± 3.74	86.05
DM	-	4.08 ± 1.40	30.20 ± 5.14	38.41 ± 3.41	32.54 ± 4.41	122.40 ± 12.05	100
COS-H	1500	7.01 ± 1.99	23.88 ± 5.86	27.04 ± 6.81b	17.88 ± 7.41b	85.79 ± 23.90b	70.09
COS-M	500	5.54 ± 1.77	22.05 ± 0.79a	28.17 ± 2.19b	17.01 ± 3.00b	84.08 ± 5.93b	68.69
COS-L	250	5.03 ± 0.51	25.62 ± 3.28	27.18 ± 2.72b	17.17 ± 4.42b	86.07 ± 8.06b	70.32

^aP < 0.05,

^bP < 0.01 vs DM group.