Protective effects of erythropoietin against acute lung injury in a rat model of acute necrotizing pancreatitis

Table 1 Pleural effusion volume and LW/BW ratios in different groups (mean ± SD)

Groups	Sham	ANP1	ANP2	ANP3	EPO1	EPO2	EPO3
Pleural effusion (mL)	0.18 ± 0.08	1.62 ± 1.08	1.5 ± 0.33	1.97 ± 0.39	0.45 ± 0.37	0.48 ± 0.38	0.85 ± 0.13
LW/BW ratio	0.003 ± 0.0004	0.006 ± 0.0022	0.007 ± 0.0016	0.008 ± 0.0019	0.004 ± 0.0008	0.005 ± 0.0009	0.005 ± 0.0011

Table 2 Serum amylase, IL-6, IL-2 and tissue MDA levels in different groups (mean ± SD)

Groups	Sham	ANP1	ANP2	ANP3	EPO1	EPO2	EPO3
Amylase (U/L)	534 ± 124	3502 ± 1830	3759 ± 1505	5056 ± 1872	1523 ± 514	2317 ± 311	735 ± 454
IL-6 (pg/mL)	4.7 ± 2.01	24.4 ± 3.26	27.7 ± 3.74	33.2 ± 2.1	12.2 ± 2.15	12.8 ± 1.89	13.8 ± 3.24
IL-2 (pg/mL)	7.4 ± 2.88	7.7 ± 3.17	9.3 ± 2.74	7.2 ± 3.1	6.9 ± 2.04	7.7 ± 2.93	10.6 ± 3.9
MDA (nmol/gr tissue)	8.5 ± 3.1	45.9 ± 6.8	49.3 ± 9.5	58.8 ± 9	14.7 ± 2.1	21.2 ± 2.7	30.4 ± 2.1

Table 3 Histopathological index scores of lung injury (mean ± SD)

Groups	Sham	ANP1	ANP2	ANP3	EPO1	EPO2	EPO3
Alveolar distention collapse	0.4 ± 0.54	0.85 ± 0.69	1.57 ± 0.78	1.71 ± 0.75	0.71 ± 0.75	1 ± 0.57	0.42 ± 0.53
Alveolar edema index	0.1 ± 0.02	0.2 ± 0.08	0.24 ± 0.05	0.28 ± 0.03	0.2 ± 0.04	0.18 ± 0.03	0.13 ± 0.04
Alveolar cellularity index	11.4 ± 8.14	17.42 ± 9.16	29.14 ± 8.39	32 ± 6.42	16.71 ± 8.61	19.85 ± 5.89	12.71 ± 7.11
PMNL cell index	1.8 ± 1.78	6 ± 3.51	8.14 ± 3.48	11.14 ± 5.55	4.71 ± 2.36	3.85 ± 2.19	1.57 ± 1.61