Correlation of matrix metalloproteinase suppressor genes RECK, VEGF, and CD105 with angiogenesis and biological behavior in esophageal squamous cell carcinoma

Table 1 RECK and VEGF expression in ESCC, atypical hyperplasia and normal mucous membrane tissues

		RECK			χ2	P	VEGF			χ2	P
	n	-	+	Positive ratio (%)			-	+	Positive ratio (%)
Normal mucous membrane tissues	62	9	53	85.5			44	18	29
Atypical hyperplasia	31	9	22	71.0	10.331	0.006	14	17	54.8	18.994	0.000
ESCC	62	25	37	59.7			20	42	67.7

Table 2 Correlation of RECK and VEGF expression with clinical and biological behavior of ESCC

	n	RECK			χ2	P	VEGF			χ2	P
		-	+	Positive ratio (%)			-	+	Positive ratio (%)
Histology grading
I	15	1	14	93.3			8	7	46.7
II	25	11	14	56	10.422	0.005	7	18	72.0	4.014	0.134
III	22	13	9	40.9			5	17	77.3
Invasion depth
Superficial muscularis	7	0	7	100			6	1	14.3
Deep muscularis	55	25	30	54.5	8.550	0.021	14	41	74.5	10.319	0.001
Lymph metastasis
N	42	13	29	69	4.751	0.029	18	24	57.1	6.693	0.010
Y	20	12	8	40			2	18	90.0

Table 3 Correlation of CD105 expression with the clinical and biological behavior of ESCC (reciprocal) (mean ± SD)

	CD105
	n	MVD	t/F	P
Histology grading
I	15	37.87 ± 3.60
II	25	37.44 ± 3.99	F = 0.885	0.418
III	22	39.00 ± 4.47
Invasion depth
Superficial muscularis	7	32.57 ± 3.46	-4.326	0.000
Deep muscularis	55	38.80 ± 3.60
Lymph metastasis
N	42	36.33 ± 3.76	4.760	0.000
Y	20	41.00 ± 3.26

Table 4 Correlation of RECK, VEGF and CD105 expressions in ESCC (mean ± SD)

RECK	n	VEGF		γs	P	MVD	t	P
		+	-
+	37	19	18	-0.427	0.001	36.00 ± 3.80	-2.969	0.004
-	25	23	2			39.10 ± 3.86